Apoptosis

New apoptosis data have been reported by researchers at Yokohama City University

Published in Cardiovascular Week, December 28th, 2009

According to recent research from Yokohama, Japan, "Ischemic injury of the heart is associated with activation of multiple signal transduction systems including the heterotrimeric G-protein system. Here, we report a role of the ischemia-inducible regulator of G beta gamma subunit, AGS8, in survival of cardiomyocytes under hypoxia."

"Cultured rat neonatal cardiomyocytes (NCM) were exposed to hypoxia or hypoxia/reoxygenation following transfection of AGS8siRNA or pcDNA::AGS8. Hypoxia-induced apoptosis of NCM was completely blocked by AGS8siRNA, whereas overexpression of AGS8 increased apoptosis. AGS8 formed complexes with G-proteins and channel protein connexin 43 (CX43),...

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Source: Cardiovascular Week (2009-12-28)

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