Cardiology

Study results from Y. Liu et al provide new insights into cardiology

Published in Cardiovascular Week, December 28th, 2009

"Daunorubicin (DNR), used as an effective antitumor antibiotic, has severe cardiac toxicity whose mechanism has remained elusive. In this study, cardiac myosin (CM) was isolated and the relationship between DNR and activity adenosine triphosphate (ATP)ase of CM at 37A degrees C was investigated for the first time," researchers in Wuhan, People's Republic of China report.

"Activity was markedly reduced with increase of DNR concentration and incubation time, which shows that DNR is involved in inhibition of physiological functions of CM. Additionally, effect of Mg2+ on Ca2+-ATPase activity of CM in presence and absence of DNR was also examined and variable effects were...

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Source: Cardiovascular Week (2009-12-28)

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