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Clinical Oncology Week

Susan Hasty, Publisher

Table of Contents . . . May 5th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Clinical Oncology Week | Other Publications

Colon Cancer - Red meat doneness and panfrying are associated most with risk

Gastrointestinal Cancer - Genetic inactivation of ACVR2 gene may indicate it is a tumor suppressor

Cervical Cancer - New approaches to cervical screening may lead to clinical benefit

Lymphoma - A significant diffuse component is a predictor for lowered survival

Metastatic Melanoma - IFN-alpha, verpamil, and dacarbazine combination can be effective

Photodynamic Therapy - Interactions of PDT with chemotherapy studied

B Cell Lymphoma - The P54-cleaved tyrosine kinase Lyn stops B cell receptor induced apoptosis

B Cell Lymphomas - MUC-1 mucin protein expression is common in any state of disease

Barrett Esophagus - Metaplasia and carcinogenesis may result from increased metallothionein

Biostatistics - A comparison of drug therapies based on toxicity and efficacy has been developed

Bone Cancer - Adamantinoma was found with discrete osteofibrous dysplasia in an ulna

Bone Marrow Transplant - Donor T cell-derived TNF is required for graft-versus-host disease

Breast Cancer - Isoliquiritigenin in licorice has estrogenic and antiproliferative activities

Breast Cancer - Organized mammography screening does not result in overdiagnosis of cancer

Breast Cancer - Percutaneous 4OHTam may be a useful alternative to tamoxifen

Breast Cancer - Peroxisome receptor gamma agonists reduce estrogen receptor alpha

Breast Cancer - Tumor suppressors p16INK4a and p14ARF are linked and not inactivated by mutation

Cancer Cell Apoptosis - The prodomain of IL-1 alpha interacts with RNA processing elements

Cancer Histochemistry - Hue-Saturation-Intensity (HSI) works better than the gold standard

Cancer Pain - Better directions and practice screens would improve PAINReportIt questionnaire

Cell Metabolism - ELF-electromagnetic fields induce apoptosis

Chemotherapy Risk - Therapy-related myelodysplastic syndrome can occur by rearrangement of MOZ gene

Chronic Osteomyelitis - Chronic osteomyelitis mimics a soft tissue sarcoma

Colon Cancer - Intestinal lymphomas should be diagnosed following universal standards

Colorectal Cancer - Colorectal cancer prognosis has improved

Colorectal Cancer - TP53 mutation status may make a difference in chemotherapeutic outcome

DNA Methylation - Human cancer cell lines have tissue type specific patterns

Epidemiology - A score test can determine non-inferiority with respect to long-term survival

Glioblastoma - Temozolomide can induce apoptosis, but resistance occurs if given in low doses

Hepatoma - Radiation causes cytotoxic conditioning of the culture medium of hepatoma cells

Hereditary Gastric Cancer - Patients have inactivated E-cadherin due to missense mutations in CDH1

Insomnia - The ZSDS single-item screen has poor sensitivity and specificity

Leiomyosarcoma - Multiple leiomyosarcomas develop after hereditary retinoblastoma

Leukemia - Bilateral femoral aseptic necrosis is the first symptom of CML

Leukemia - F11782 topoisomerase inhibitor induces apoptosis through Bax and caspase action

Leukemia - Fludarabine accumulation in CLL is mostly mediated by ENT-type transporters

Lung Cancer - Lung ossification may be due to metastatic spread of colorectal adenocarcinomas

Malignant Melanoma - The density of hair is inversely related to pigmented lesion count

Mediastinal Hemangioma - A rare case of sclerosing hemangioma is isolated to the mediastinum

Melanoma - Glucocorticoid hormone resistance may be due to increased STAT3 and PI-3 kinase

Melanoma - Increasing oxygen and acidity by glucose/iodobenzylguanidine may improve outcome

Metastatic Melanoma - Fotemustine plus whole brain irradiation works better than fotemustine alone

Myeloma - Osteoprotegerin is a decoy receptor for TRAIL ligand, protecting from apoptosis

Nasopharyngeal Carcinoma - Nasopharyngeal cancer pain during radiation therapy is often undertreated

Occupational Exposure - TP53 mutations may act as fingerprints for exposure to specific carcinogens

Ovarian Cancer - Height, more than body mass, is positively associated with ovarian cancer risk

Premalignant Lesions - Endometriosis doesn't appear premalignancy-based when tested for clonality

Radiation Damage - No chromosomal instability was found in radiation exposed normal fibroblasts

Radiotherapy - Cytokine activation sensitizes hematopoietic cells to cisplatin-induced death

Skin Cancer - UVA radiation produces apoptosis of immortalized human keratinocytes

T Cell Malignancy - HTLV-1 Tax oncoprotein binds to a PDZ domain of the IL-16 precursor

Topoisomerase Inhibitors - Increased CD26/dipeptidyl pepticlase IV on cell membrane increases sensitivity

Tumor Invasion - Higher CD44 or lower E-cadherin can increase tumor spread

UV Damage - Epidermal growth factor signaling pathway is impaired by oxidative stress

Ulcerative Colitis - Sporadic adenoma and intraepithelial neoplasia are difficult to distinguish

Validity/Reliability Studies - Two parameters need to be estimated in validity/reliability studies

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