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Cancer Cell Biology

CYC202 induces cancer cells to commit suicide

Published in Clinical Oncology Week, August 25th, 2003

Cyclacel, Ltd. has demonstrated that CYC202 (R-roscovitine), its lead CDK inhibitor drug candidate, appears to induce cancer cell suicide or apoptosis in patients receiving the drug. Details of the biomarker data obtained with CYC202 were reported at an oral presentation at the American Association for Cancer Research (AACR) annual meeting in Washington, DC.

Biomarker technology is used to understand the molecular mechanism of action of novel drugs in humans, provide insights into their pharmacological properties, measure their biological effect (e.g., induce cancer cells to commit suicide) and determine susceptibility or resistance to the treatment. In the long-term,...

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