Myeloma Oncogenesis
Early plasma cell dyscrasia can have IgH rearrangements deregulating cyclin D1
Published in Clinical Oncology Week, August 25th, 2003
"Chromosomal translocations involving the immunoglobulin heavy chain gene (IgH) and nonrandom protooncogene loci are the hallmark of genetic alterations found not only in multiple myeloma (MM), but also in premalignant stages of MM, including monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM)," scientists in Japan report.
"We studied the frequency of IgH (14q32) rearrangements and their partner chromosomes in 16 Japanese patients with MGUS (13 cases), and SMM (3 cases)...
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