Published in Clinical Oncology Week, September 29th, 2003
"Microtubule-interacting drugs are important agents in cancer chemotherapy. Some of these drugs alter microtubule dynamics and engage the cell cycle surveillance mechanisms to arrest cell division in mitosis," scientists in the United States report.
"Many cancer cells possess genetic lesions in components of this pathway and thus fail to arrest in mitosis," wrote P.M. Checchi and colleagues, Emory University School of Medicine.
"Therefore, by targeting the spindle microtubules, chemotherapeutic agents can efficiently block cell cycle progression in...
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