Pharmaceutical & Drug Development
Microwave accelerated oligonucleotide labeling expands research possibilities
Published in Clinical Oncology Week, March 29th, 2004
"Oligonucleotides are extensively used for characterization of gene expression in vitro and have now been studied as inhibitors of gene expression in vivo in various diseases. Labeled antisense oligonucleotides are therefore of potential interest for possible in vivo imaging of gene expression, considering the biology of tumors and applications in designing novel molecule-targeted therapies. In the present work a method of microwave accelerated Ga-68-labeling of oligonucleotides and analysis of the resulting tracers are described," investigators in Sweden report.
"Four...
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