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Clinical Oncology Week

Susan Hasty, Publisher

Table of Contents . . . November 15th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Clinical Oncology Week | Other Publications

Arthritis - Results from two REMICADE studies presented at conference

Glioma - N-cadherin expression inversely correlates with glioma tissue invasion

Gynecology - Insulin-like growth factor 1 promotes the dissemination of gynecological cancer

Osteosarcoma - Smooth press-fit stem enables post-resection physeal growth in children

Testicular Cancer - Factors influencing decision on testicular prosthesis identified

Alzheimer Research - Drug developer, Georgetown University awarded grant to develop Alzheimer drug

Anticancer Therapy - U.S. patent covers various routes of administration of adenoviral p53

Aspergillosis - Liver iron overload after SCT associated with invasive aspergillosis

Autoimmune Disease - Researchers discover function of Lag-3 gene

Awards - Biopharm company is finalist for innovative product award in biotechnology R&D

Bladder Cancer -  N-acetyltransferase 1 involved in arylamine activation

Bone Cancer - MRI discloses tumor angiogenic activity in patients with osteosarcoma

Bone Marrow Transplantation - B-cell depletion in BM transplant correlates with significantly lower EBV load

Bone Marrow Transplantation - Minority of BMT patients with myeloid leukemia has cognitive/sexual impairment

Brain Cancer - Angiogenic cytokines have diverse effects on astrocytoma neovascularization

Brain Cancer - Cellular immunity and immunotherapy of brain tumors reviewed

Brain Cancer - Study blocks mechanism that lets brain tumors sidetrack immune response

Brain Tumors - Data presented on GliaSite Radiation Therapy for recurrent brain tumors

Breast Cancer - Biopsy tool developed for MastaScope, tool under clinical investigation

Breast Cancer - Incidence in Asian Americans rising faster than any other U.S. ethnic group

Breast Cancer - Massachusetts clinic helps patients cope with breast cancer

Breast Cancer - New radiotherapy regime benefits young patients

Breast Cancer - Oncostatin M induces S100A9 gene expression in breast tumor cells

Breast Cancer - Reconstruction with postmastectomy radiation therapy not problem free

Breast Cancer - San Diego Susan Komen foundation affiliate presents 'Bras Down Broadway'

Breast Cancer - Survivors' recurrence risk, weight gain reduced with physical activity

Business and Finance - Pharmaceutical company restructures

Cancer Growth Factors - Host-derived plasminogen activator inhibitor-1 sustains tumoral angiogenesis

Cancer Research - Biotech company initiates second phase 1 study of SNS-595 for cancer

Cancer Research - Exclusive license granted for measuring DNA methylation of the RASSF1A gene

Cancer Research - Experimental reovirus-based cancer therapy kills host cells, researchers find

Cancer Risk - Raw vegetable consumption decreases cancer risk

Cancer Therapy - Drug group says E.U. body may give quick approval cancer drug

Cancer Therapy - Genomic effects of green tea EGCG elucidated

Cancer Therapy - Research data on a novel DNA purification method released

Cancer Therapy - Six-year-old battling cancer is her mother's hero

Cancer Vaccine - Preclinical data demonstrates promise of INGN 225 therapy as cancer vaccine

Carcinogenesis - Hepatitis B virus X protein causes the aberrant expression of numerous genes

Carcinogenesis - Vitamin D encourages VEGF expression in murine fibroblasts

Cellular Therapy - Cell line manufacturer signs license for liver cells

Cervical Cancer - Estrogen and progesterone receptors, bcl-2 are biomarkers for CIN III

Cervical Cancer - Impaired antioxidant system may play role in cervical neoplasia

Cervical Cancer - Irradiation and concurrent chemotherapy regimen studied

Cervical Cancer - Pelvic lymph nodes appear to be good predictors of parametrial status

Cervical Cancer - Study shows benefits of surgical resection of locally recurrent cancer

Cervical Cancer - Tamoxifen doesn't show antitumor activity in nonsquamous cell cervical cancer

Cervical Cancer - p14(ARF) and p16(INK4A) overexpression associated with HPV-positive cancer

Colorectal Cancer - Doctors can improve screening rates in the U.S. among women and Hispanics

Complementary & Alternative Medicine - British Wal-Mart subsidiary Asda fined over mango cancer-fighting powers

Complementary and Alternative Medicine - St. John's wort reduces effectiveness of anticancer medication

Drug Development - Pharma company completes humanization of 3G4 antibody

Finance - Biotech completes new financing

Finance - Pharmaceutical company announces third quarter performance, EPS of $0.60

Finance - QUADRAMET maker revises 2004 financial outlook

Gastroenterology - Diagnosis and treatment of pediatric H. pylori infection reviewed

Genetic Profiling - Genetic testing company launches mutation detection kit for eight disease states

Glioblastoma - Recombinant anti-HER2/neu antibody causes tumor cell death

Graft-Versus-Host Disease - Mycophonolate mofetil added to CsA does not significantly reduce aGVHD

Gynecologic Cancer - Extraovarian nongestational choriocarcinoma reported in postmenopausal woman

Gynecologic Cancer - Laparoscopic pelvic and para-aortic lymphadenectomy prevails over laparotomy

Hearing Loss - New study says MRI is best test for sensorineural hearing loss

Human Papillomavirus Vaccine - Prophylactic human papillomavirus vaccines reviewed

Imaging - Trial explores whole-body MRI to detect cancer, focus treatment in children

Liver Cancer - Lamivudine resistance is a risk factor for HBV-related hepatocellular carcinoma

Lung Cancer - Higher radiation doses help some lung cancer patients live longer

Lung Cancer - Occupational exposure to acrylonitririle increases risk of lung cancer

Lymphoma - High-dose treosulfan induces complete remission in relapsed high-grade lymphoma

Malaria - Study shows Corixa's MPL adjuvant protected against uncomplicated malaria

Medical Devices - Hemorrhoid treatment trial presented at the family doctors conference

Medical Devices - Mass spectrometer for complex analysis selected for R&D 100 Award

Melanoma - Melan-A/MART-1 expression in primary melanoma cell cultures indicates survival

Mergers & Acquisitions - Biotechnology companies revise merger terms

Mergers & Acquisitions - Pharma companies' joint proxy statement cleared by SEC

Metastasis - Potential new oncogene may be missing link in cancer-causing chain

Metastasis - Sandbagging cancer in the bloodstream prevents it from traveling

Multiple Myeloma - No relation between cell harvest and outcome success after PBSCT in MM

Multiple Myeloma - Research foundation awards 3-year grant to study molecular multiple myeloma

Multiple Myeloma - Single-agent dexamethasone effective for MM pre-SCT induction therapy

Mutation - Cascade testing of familial hypercholesterolemia families is cost effective

Mutation - Disease-causing RyR2 mutations enhance RyR2 luminal CA2+ activation

Mutation - Familial hypercholesterolemia phenotype is influenced by other factors

Nutrition - Strong-flavored onions show promise for fighting cancer

Occupational Health - Dose/age associated with translocation frequency in low-dose radiation exposure

Occupational Health - Vinyl chloride intensifies the effects of alcohol and viruses on liver diseases

Oncology - Androgen withdrawal halts new vessel growth in prostate cancer models

Oncology - Company inks multiyear agreement with LabCorp for ThinPrep Imaging System

Oncology - Drug discovery company presents study results at EORTC-NCI-AACR symposium

Oncology - Gene expression profiles yield clinicopathological staging of colorectal cancer

Oncology - Interface development collaboration for data management solutions announced

Oncology - New cancer target the focus of monoclonal antibody treatment

Oncology - New technology prevents breast cancer development in transgenic mice

Oncology - Oncologist disputes American Society of Clinical Oncology task force claim

Osteogenic Sarcoma - Spalteholz technique used to determine canine tumor microvasculature

Ovarian Cancer - Early ovarian cancer plus tuberculosis mimics advanced ovarian cancer

Pain - Site-specific drug relieves pain after gynecologic cancer surgery, study shows

Pain Management - Study shows massage therapy popular for pain relief

Patents - Diomed initiates patent infringement litigation

Personnel - Biosciences company adds member to scientific advisory board

Personnel - Cancer therapy provider appoints member to board

Personnel - Gregory Berk, MD, named chief medical officer and VP of biosciences company

Personnel - James Thompson, MD, named to senior medical director position

Personnel - Kathrin U. Jansen, PhD, named senior VP and CSO at vaccine company

Personnel - Leo Furcht, MD, joins board of directors of migraine company

Personnel - Pharma company announces board changes/additions

Personnel - Pharmaceutical company promotes Ann Cahill to senior management team

Prognostics - New protein associated with aggressiveness in breast and ovarian cancer

Prostate Cancer - Hedgehog pathway linked to advanced stages of prostate cancer

Prostate Cancer - Prostate Cancer and Asian diet examined by study

Prostate Cancer - Study to define maximum tolerated dose of INSM-18 in prostate cancer patients

Radiotherapy - Companies collaborate to create unique radiotherapy treatment

Restructuring - Genomics-based company to focus on its therapeutic pipeline

Skin Cancer - Skin cancer mortality rates declining in Europe

Stem Cell Transplantation - Clinical benefits of reduced-intensity ASCT for CTCL are short lived

Stem Cell Transplantation - Macrolide immunosuppressant sirolimus controls GVHD after ASCT

Tumor Biology - Angiopoietin-2 may control the angiogenic switch in growing tumors

Vulvar Cancer - Specific factors identified to add to vulvar cancer-specific QOL subscale

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