Cervical Cancer

Plasma HPV DNA may be useful to monitor therapy and disease progression

Published in Clinical Oncology Week, November 22nd, 2004

Measuring levels of human papillomavirus DNA in plasma of women with cervical cancer may be useful for monitoring response to therapy and disease progression, suggest researchers at the University of Hong Kong.

To evaluate the clinical usefulness of circulating DNA for cervical cancer management, H.J. Yang and colleagues quantified "DNA extracted from pretreatment plasma of 50 cervical cancer patients and from serial longitudinal plasma of 21 patients ... for HPV16/HPV18 by means of quantitative polymerase chain reaction. Another 15 patients with low-grade lesion (LG), 18 patients with high-grade lesion (HG), and 96 normal individuals were studied as controls."

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Source: Clinical Oncology Week (2004-11-22)

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