Oncogenesis

Adenoma to carcinoma hTR expression not linked to promoter methylation

Published in Clinical Oncology Week, November 22nd, 2004

Increased hTR expression during transition from adenoma to carcinoma is not associated with promoter methylation.

According to recent research published in the journal Digestive Diseases and Sciences, "Human telomerase RNA component (hTR) expression, which increases in the majority of cancer cells with an acquisition of telomerase activity, was concomitantly evaluated with methylation status and human telomerase reverse transcriptase (hTERT) expression in colorectal cancers and precursor lesions. hTR and hTERT expressions were detected by in situ hybridization and reverse transcription following polymerase chain reaction, respectively, in 15 colonic adenomas, 19...

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Source: Clinical Oncology Week (2004-11-22)

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