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Prostate Cancer

Luteinizing-hormone-releasing-hormone causes prostatic atrophy

Published in Clinical Oncology Week, November 22nd, 2004

A recombinant luteinizing-hormone-releasing-hormone immunogen is effective in causing prostatic atrophy.

"Previous studies with a semi-synthetic vaccine indicated the utility of immunization against luteinizing-hormone-releasing-hormone (LHRH) in prostate cancers. To overcome the limitations of the previous vaccine, which caused carrier induced suppression of antibody response on repeated immunizations and was costly to synthesize, two recombinant vaccines were designed, in which diphtheria or tetanus toxoid used as carriers were replaced by 4-5 T non-B peptides," scientists in India report.

"The paper reports the immunogenicity, efficacy and safety...

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