Acute Myelogenous Leukemia

Phenotypic karyotype markers identified in AML with t(8;21)

Published in Clinical Oncology Week, November 22nd, 2004

Phenotypic markers of karyotype have been identified in acute myelogenous leukemia (AML) patients with the t(8;21) translocation.

AML "with t(8;21) is a distinct clinicopathologic entity in which the malignant myeloblasts display a characteristic pattern of surface antigen expression," pathologists in Canada explained. "Quantitative analysis of surface marker expression in patients with this chromosomal abnormality compared to acute myelogenous leukemia patients with a different karyotype has not been reported."

"From 305 consecutive newly diagnosed acute myelogenous leukemia patients underwent immunophenotyping and cytogenetic analysis at our...

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Source: Clinical Oncology Week (2004-11-22)

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