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Clinical Oncology Week

Susan Hasty, Publisher

Table of Contents . . . February 28th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Clinical Oncology Week | Other Publications

Breast Cancer - Obesity and weight gain associated with poorer breast cancer survival

Breast Cancer - Radar-based imaging system penetrates dense breast tissue

Oncogenesis - Recent findings in oncogenesis provide new insights

Oncology - Gelatinase inhibitors warrant scrutiny when used as cancer therapy

Oncology - ROCK inhibitors can block angiogenesis and cancer metastasis

Proteomics - Soluble TWEAK protein generates highly vascularized tumors

Acute Myelogenous Leukemia - Genes with prognostic value identified in AMLs with normal karyotype

Acute Myeloid Leukemia - XPD genetic variation predicts treatment outcome and AML risk after chemotherapy

Alzheimer Disease - Nanotechnology company expands application of Alzheimer detection technology

Biomedical Engineering - University of Arkansas for Medical Sciences adopts tissue management system

Brain Cancer - The attenuated adenovirus ONYX-015 fights glioma proliferation

Breast Cancer - Breast myoepitheliomas should be managed as potentially malignant tumors

Breast Cancer - CYP17 gene variant interactions affect breast density, possibly cancer risk

Breast Cancer - Common variant of CASP8 gene associated with reduced risk of breast cancer

Breast Cancer - Company expects its system to be part of NCI partial breast irradiation study

Breast Cancer - Estrogen receptor genetic variants and cancer risk investigated

Breast Cancer - Ethnic differences in breast density to be examined

Breast Cancer - FDA approves InSite Her-2/neu Kit

Breast Cancer - Fashionable to Care program launches to support breast cancer research

Breast Cancer - Identification of second breast cancer gene announced

Breast Cancer - Medical imaging company plays role in clinical trial of drug for breast cancer

Breast Cancer - New immunotherapeutic approach evaluated for advanced disease

Breast Cancer - Platelet-derived LAP supports progression of osteolytic bone metastases in mice

Breast Cancer - Study seeks to clarify hypothyroidism/breast cancer association

Breast Cancer - Tamoxifen treatment reduces patients' risk of heart disease

Breast Cancer - Technology company uses virtual clones to predict breast cancer therapy

Breast Cancer - Truck driver occupation linked to increased BRCA1/2 male breast cancer mutation

Business & Finance - Biotech company reports pipeline update, financial performance

Business Update - Boehringer Ingelheim to discontinue development of bivatuzumab mertansine

Business Update - Companies amend milestones in cancer agreement

Business Update - Disease management company awarded new accounts

Business Update - PREVU* POC Skin Sterol Test available for sale in Canada, U.S. markets

Business Update - Pharma company adds to product line, enters partnership

Business Update - Pharma company signs sales and marketing contract for OTC Products

Business Update - Report: Emerging technologies will bring improved mAb-based products

Business Update - Vaccine developer may receive milestone payment for human papillomavirus vaccine

Cancer Genetics - BRCA2-related protein repairs broken DNA

Cancer Research - DAVANAT and DAVANAT/5-FU well tolerated in patients with advanced solid tumors

Cancer Research - Society launches Daffodil Days campaign to raise money through Flower of Hope

Cancer Research - U.S. government releases updated list of cancer-causing agents

Cancer Risk - Larger babies have higher risk of certain cancers in adulthood

Cancer Risk Factors - COX-2 levels parallel microvessel density in non-melanoma skin cancer patients

Cancer Risk Factors - Overexpressed c-Myc in liver disease patients may cause liver cancer

Cancer Survival - Child cancer survivors get high scores

Cancer Therapy - $10M funds study to determine men's role in HPV transmission

Cancer Therapy - 5-fluorouracil inhibits exosome-dependent degradation of polyadenylated rRNAs

Cancer Therapy - Activated JNK in mitochondria linked to paclitaxel-induced cytotoxicity

Cancer Therapy - Fusion transgene elicits a robust immunological response to tumor cells

Cancer Therapy - Host immune system should be considered when treating MSI tumors

Cancer Therapy - Mutant epidermal growth factor receptor enhances susceptibility to ZD6474

Cancer Therapy - New cancer prevention technology prevents polyps from turning into colon cancer

Cancer Therapy - Pharma company announces orphan drug designation accepted for RX-0201

Cancer Therapy - Recent studies add new data to cancer therapy research

Cancer Therapy - Researchers describe findings in cancer therapy studies

Cancer Therapy - SU5416 treats lung cancer by blocking Kit-induced VEGF expression

Cancer Vaccine - CD1d-dependent NK T cells are adjuvants in T cell-mediated immunotherapy

Cancer Vaccine - Functional memory CD8+ T cells generated in vivo without evident T help

Cancer Vaccine - Prolonged culture of vaccine-primed lymphocytes decreases antitumor killing

Carcinogens - Eugenol metabolites produce DNA damage in human genes

Cervical Cancer - IL-10, TNF-alpha levels may indicate stage of cervical lesions induced by HPV

Cervical Cancer - Researchers' data advance cervical cancer research

Chernobyl Cancer Risk - Statistically significant cancer increase in most contaminated Chernobyl region

Chronic Lymphocytic Leukemia - Withdrawal of clinical trial protocol in chronic lymphocytic leukemia announced

Clinical Trials - Suicide gene therapy prolongs the survival of patients with malignant glioma

Collaborations - Curis to co-develop cancer drug

Colon Cancer Risk - ALOX and COX polymorphisms influence colon cancer risk in Caucasians

Colorectal Cancer - Benefit of Eloxatin-based chemo plus bevacizumab for colorectal cancer reported

Colorectal Cancer - Results presented for Avastin plus the FOLFOX4 chemotherapy regimen

Complementary & Alternative Medicine - Researchers blend folk treatment, high tech for promising anticancer compound

Congestive Heart Failure - Long-standing anemia of any cause can cause left ventricular hypertrophy

Crohn Disease - Study evaluates new treatment in Crohn Disease

Cutaneous Malignant Melanoma Risk Factors - Inverse association between vitamin A and cutaneous malignant melanoma risk

Cytomegalovirus - Treatment for AIDS-related cytomegalovirus receives positive recommendations

Diagnostics - Companies launch strategic alliance for cancer studies

Diagnostics - Technology company introduces ImageChecker LS CAD system

Diet & Nutrition - Health benefits of citrus limonoids explored

Drug Development - Cancer-focused drug company expands development program for lead cancer drug

Drug Development - Company announces new indication, CLL, for GCS-100LE clinical trial program

Drug Development - FDA approves nasal spray for B12 deficiencies

Drug Development - Three-year agreement with GSK supports drug discovery and development efforts

Endocrinology - New field - intracrinology - describes local formation of sex steroids

Exercise - Predictors of adherence to exercise in colon cancer survivors reported

Finance - Cancer-focused pharmaceutical co. completes $32.5 million sale of common stock

Finance - Imaging device company announces fourth quarter and year-end 2004 results

Finance - Pharma company announces first quarter 2005 financial results

Finance - Pharma company reports improved financial results

Finance - Radiation therapy company reports third quarter financial results

Gastric Cancer - Expression analysis identifies alterations in AP-1 pathway induced by gastrin

Gene Research - Genetic test company licenses markers for Ashkenazi Jewish multi-disease panel

Genetic Engineering - Genetically modified cytolytic T cells recognize and kill glioblastoma

Genetics and Genomics - HLA profiles differ with cancer type in hepatitis C virus-positive patients

Glioma - PTEN regulates c-Met-dependent gene expression in glioma cells

Gynecologic Cancers - MIS plus X-linked clonality analysis helps diagnose synchronous tumors

HIV/AIDS Testing - HIV testing campaign targets African American and Latina women

Healthcare Coverage - Changes in reimbursement structure to aid greater adoption of brachytherapy

Heathcare Coverage - PET equipment maker comments on Medicare and Medcaid coverage for PET

Hematology - Lamivudine-induced mutants may link hepatitis B to acute myeloid leukemia

Hepatitis C Therapy - PEGASYS combination therapy approved for hepatitis C/HIV coinfection in Europe

Human Papillomavirus Vaccine -  Listeria vaccines containing PEST sequences are adjuvants for HPV16 E7

Human Papillomavirus Vaccine - Plasmid encoding HPV DNA improved immunogenicity against HPV infection

Human Papillomavirus Vaccine - Synthetic HPV16 E7 protein is immunogenic in the TC-1 mouse tumor model

Imaging - Nano-sized probes allow Penn researchers to see tumors through flesh and skin

Information Technology - Texas university's cancer center web site is fourth most visited hospital site

Leukemia - Drug fights pre-leukemia condition in two ways

Leukemia - TYK2 appears to be a key regulator of the surveillance of B lymphoid tumors

Licensing - German pharmaceutical company announces licensing agreement with Pfizer

Liver Cancer - Drug delivery technology shows positive results in liver cancer

Liver Cancer - Hepatitis C virus core protein encoded in hepatocellular carcinomas

Liver Cancer - Researchers report details of new studies and findings in the area of liver cancer

Liver Cancer - Tocotrienol-rich fraction intake may prevent hepatocarcinogenesis

Lung Cancer - CyPA and MIF do not have prognostic value in NSCLC patients

Lymphoma Therapy - Anti-CD20 antibody-drug conjugates show promise for B-cell lymphoma treatment

Melanoma - Tissue microarrays used to analyze expression of DNA mismatch-repair genes

Melanoma Vaccine - Cancer antigen heterogeneity in melanoma is methylation-regulated

Multiple Myeloma - Companies advance PXD101 into phase II clinical program

Multiple Sclerosis - Interferon-focused company begins enrollment for phase 2 trial of MS treatment

Muscular Dystrophy - Orphan drug designation granted to PTC124 for Duchenne muscular dystrophy

Myeloma - IMF applauds Medicare decision to expand PET scan coverage for myeloma patients

Neurology - Infection in newborn rats exhibit memory problems during later immune challenge

Neuroscience - Recurrent solitary fibrous tumor with cerebrospinal fluid dissemination reported

Non-Hodgkin Lymphoma - Injection for non-Hodgkin lymphoma shows promising activity in 2 phase 2 studies

Non-Small Cell Lung Cancer - Company Initiates phase I/II clinical trial of PT-523 in NSCLC

Nutrition - Carrot component reduces cancer risk

Obstetrics - LEEP treatment increases risk of preterm delivery in future pregnancies

Oncogenesis - Findings in oncogenesis provide new insights

Oncology - CEACAM1 is an angiogenic switch in urinary bladder cancer

Oncology - Endothelin receptor B is a strong regulator of melanoma progression

Oncology - Inherited gene sequences dictate VEGF activity in non-small cell lung cancer

Oncology - Lamivudine prevents hepatitis B reactivation during breast cancer therapy

Oncology - Microarray discerns DNA changes in microdissected ovarian cancer specimens

Oncology - Percutaneous placement of peritoneal port-catheter safe and effective

Oncology - Ras oncogene promotes hypoxia-inducible factor-1alpha-related tumor growth

Oncology - Transforming growth factor beta 1 accelerates tumor metastasis

Oncology - VEGF is a target for the management of multiple myeloma

Oral Cancer - Product containing Zila Tolonium Chloride cleared by FDA

Ovarian Cancer - Endometrioid carcinomas have lower MIS rate and PTEN changes than uterine type

Ovarian Cancer - Immunohistochemical expression of cadherin-catenin complex studied

Pancreatic Cancer - Novel radioimmunoconjugate targets metastatic tumor cells

Pancreatic Cancer - Partnership to develop pancreatic cancer therapies announced

Pathology - Sprouting dominates VEGF-induced tumor neovascularization

Personnel - Biopharma company names vice president of process sciences

Personnel - Biotechnology company appoints vice chairman

Personnel - Cancer-focused biopharmaceutical company appoints 2 to development positions

Personnel - Cancer-focused company names Pieter Timmermans senior VP Preclinical Development

Personnel - Clinical research organization announces management changes, new board member

Personnel - Medical advisory board member named to U.S. National Advisory Eye Council

Personnel - Oncology-focused biopharmaceutical company names James Hawley senior VP

Personnel - Pharma company hires new head of drug development

Personnel - Pharma development company adds members to board of directors

Personnel - Pharmaceutical company adds member to board

Philanthropy - Retail shoe company donates $570,000 to breast cancer foundation

Prostate Cancer - Biotechnology company to initiate clinical trial for prostate cancer

Prostate Cancer - New agents being developed for prostate cancer prevention

Prostate Cancer - Recent studies add new data to prostate cancer research

Prostate Cancer - Researchers describe findings in prostate cancer studies

Proteomics - Adenoviral E1A uses the mdm4 protein to stabilize tumor suppressor p53

Proteomics - Endostatin relies on a heparin-binding motif for angiogenesis suppression

Renal Cell Carcinoma - Endoprosthetic elbow replacement effective as treatment for single metastasis

Retrovirus - Human retroviruses in leukemia and AIDS reviewed

Retrovirus - Murine leukemia virus cleared by flocculation and microfiltration

Sexual and Reproductive Health - Supplemental NDA confirmed for lasofoxifene as a treatment for vaginal atrophy

Small Cell Lung Cancer - Tissue microarrays are not suitable for diagnosis of individual patients

Stem Cell - Therapeutics company announces fast track designation for stem cell product

Stroke - Biotechnology firm receives fast-track status for antistroke treatment

Sweet Syndrome - Anti-TNF-alpha antibody effective in patient with refractory disease

Thrombosis - Patients with cancer have highly increased risk for blood clots

Thrombosis - Study compared traits of adolescent thrombosis patients with child patients

Thyroid Microcarcinoma - BRAF(T1796A) transversion prevalent mutational event in thyroid microcarcinoma

Transplant Medicine - Circles of DNA might help predict success of stem cell transplantation

Transplant Medicine - Immunology company announces bone marrow transplant trial

Transplant Medicine - New stem cell source could boost bone marrow success

Vaccinia Virus - Modified vaccinia virus Ankara as antigen delivery system reviewed

Virology - New data illuminates research in virology

Virology - Oncolytic mutant adenovirus destroys solid tumors

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