Susan Hasty, Publisher
Table of Contents . . . March 14th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Clinical Oncology Week | Other Publications
Cancer Diagnostics - Markers distinguish primary ovarian tumors from metastatic colorectal cancer
Cancer Risk Factors - Obesity associated with progression of prostate and renal cell cancer
Chemotherapy - Most concerns of female cancer patients aren't identified by nurses
Lung Cancer Therapy - Docetaxel approved for treatment of advanced non-small-cell lung cancer
Pituitary Cancer - Transsphenoidal surgery effective for secreting pituitary tumors
Allergy and Immunology - Local gene therapy can help dendritic cells fight tumor growth
Allergy and Immunology - Thymalfasin shows promise for treating viral hepatitis and cancer
Alzheimer Disease - Phase 2 clinical study for Alzheimer disease completed
B-Cell Lymphoma - Flow cytometry useful for detection of occult CSF involvement
Biomedical Engineering - Biotechnology company reports progress in avian transgenics biomanufacturing
Biomedical Engineering - Interleukin-12 fusion protein and homing peptide eradicate neuroblastoma
Cancer Genetics - Researchers report details of new studies and findings in the area of cancer genetics
Bioterrorism - Company initiates animal studies on compound to treat exposure to terror weapons
Bladder Cancer - Dietary carotenoids and genetic instability modify bladder cancer risk
Bladder Cancer - HER3 and HER4 expression associated with better survival in bladder cancer
Brain Cancer - Proton magnetic resonance spectroscopic imaging provides pediatric biomarkers
Brain Tumor - Treatment for brain tumors granted orphan designation in Japan
Breast Cancer - Breast cancer foundation hosted annual conference
Leukemia - Recent findings in leukemia provide new insights
Breast Cancer - Candidate genes in breast tumors identified through matrix-CGH analysis
Breast Cancer - Colorado imaging group offers MRI scanning for breast cancer detection
Breast Cancer - Endothelin-1 increases breast tumor perfusion in rats
Breast Cancer - Entities collaborate to analyze DNA samples from breast cancer patients
Breast Cancer - FAK upregulation in ductal carcinoma in situ is early event in tumorigenesis
Breast Cancer - Investigator-sponsored phase 1 trial data of breast cancer treatment presented
Oncology - Reports advance knowledge in oncology research
Breast Cancer - New MRI-based imaging method may improve breast cancer detection
Breast Cancer - Nucleolar size and activity related to pRb, p53 status in human breast cancer
Breast Cancer - Studies describe new findings in breast cancer research
Breast Cancer - Survey finds women will be inconvenienced for noninvasive biopsy procedures
Breast Cancer Risk Factors - Integrin beta(3) Leu33Pro polymorphism may increase breast cancer risk by age 45
Business & Finance - DNA-focused biopharmaceutical company announces fourth quarter, year end results
Business Update - Company to expand Cesium-131 production through leased new facility
Business Update - Sales accountability company teams with medical device manufacturer
Cancer Genetics - Researchers publish new studies and findings in the area of cancer genetics
Cancer Metastasis - Cervical node lesions and inflammatory changes look similar on ultrasound
Cancer Metastasis - Tight junction protein levels decline in metastatic breast cancers
Cancer Screening - Model predicts live-saving benefits of different mammography schedules
Cancer Therapy - Akt activation can promote resistance to microtubule-directed agents
Cancer Therapy - Caveolin gene delivery diminishes tumor angiogenesis by targeting nitric oxide
Cancer Therapy - Liposome-encapsulated lipophilic gemcitabine prodrugs synthesized
Cancer Therapy - Novel breast cancer cell line may aid research on trastuzumab resistance
Cancer Therapy - Strategies to disrupt anti-apoptosis protein must overcome major hurdles
Cancer Therapy - Tyrosine kinase inhibitors disrupt malignant mesothelioma growth factors
Cardiovascular Disease - There is a potentially profound overlap between CV conditions and cancer
Cell Biology - CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
Cell Biology - Research reveals insights into how oncogenic protein regulates cell growth
Chronic Liver Disease - Protein profiles find cancer markers in patients with chronic liver disease
Chronic Lymphocytic Leukemia - Paper published in immunology journal describes action of T cell product in CLL
Chronic Lymphocytic Leukemia - Safety and efficacy of cladribine in CLL treatment clarified
Coccidian Parasite - C. cayetanensis important parasite in immunocompromised persons
Collaborations - First groundbreaking held in U of California San Diego Science Research Park
Collaborations - Hospital and university partner to develop health service and education programs
Collaborations - Platinum IV compound licensed from M.D. Anderson Cancer Center
Colon Cancer - Age-related ERRP loss in aging colon is potential risk factor for colon cancer
Colon Cancer - Ring finger protein 43 may be novel immunotherapy target
Colon Cancer - Tumor proteins linked to C225 resistance identified
Colorectal Cancer - Patient enrollment completed for HGS-ETR1 phase II trial in colorectal cancer
Coronary Artery Disease - A high percent of CAD/MI population may carry mutations in MEF2A
Cutaneous T Cell Lymphoma - HuMax-CD4 shows encouraging duration of response data in T cell lymphoma
Diagnostics - Arginine-arginine-leucine augments tumor vessel imaging
Diagnostics - Assays used to identify potential treatments for drug-resistant strain of HIV
Diagnostics - Elispot assay optimized to detect cytomegalovirus-specific CD8+ T lymphocytes
Diagnostics - Test to check for bladder cancer more reliable than cystoscopy, study shows
Diet & Nutrition - Biotech company enters alliance to launch Resurgex and Resurgex-Plus
Drug Delivery - Novel norcantharidin microemulsions formulated for parenteral use
Drug Development - Cobalamin-colchicine conjugate shows promise as tumor-targeted cytotoxin
Drug Development - Lipid methotrexate derivative synthesized
Drug Development - Novel retinoic acid metabolism blocking agents have antitumor activity
Emergency Medicine - Ruptured gastrointestinal stromal tumor mimics acute appendicitis
End-of-Life Care - Referrals to palliative care come too late to improve life for cancer patients
Epidemiology - Recent studies add new data to epidemiology research
Epidemiology - Water is a major vehicle for Cryptosporidium transmission
Esophageal Cancer - Genes linked to esophageal squamous cell carcinogenesis identified
Finance - Cardiovascular therapeutics company reports second quarter fiscal 2005 results
Finance - Diagnostics company reports quarterly, year-end financial results
Finance - Fine chemicals manufacturer reports third quarter fiscal 2005 results
Finance - Radiation therapy company reports strong fourth quarter results
Gastric Cancer - Obesity increases risk of gastrointestinal malignancies
Gene Research - CuraGen exercises option to expand antibody-drug conjugate collaboration
Gene Research - Separating chromosomes may improve genetic test results, study shows
Genotoxicity - Multiple factors contribute to mechanism of particulate matter genotoxicity
Glioma - Drug in trials to treat glioma obtains orphan drug designation in Japan
Gynecology - Adeno-associated virus vector transmits therapeutic ligand to ovarian cancer
HIV/AIDS Diagnostics - BM biopsy not sensitive as diagnostic tool in AIDS patients with fever
Hairy Cell Leukemia - Rituximab may be effective as salvage therapy for Japanese variant HCL
Head and Neck Cancer - Cyclin D1 overexpression alone does not cause salivary gland cancer growth
Hepatitis C - Association noted between certain nonliver cancers and hepatitis C in Sweden
Hepatitis C Therapy - Drug development companies to codevelop recombinant human alfa interferon
Hepatocellular Carcinoma - DNA repair genes upregulated in cancer-related cirrhosis
Hypertension - Essential hypertension may be mildly influenced by the MTHFR C677T variant
Information Technology - Hospital physicians utilize information technology to improve patient care
Information Technology - New York hospital selects emergency department information management system
Information Technology - Pen-and-paper technology that transforms writing into digital text introduced
Insulinoma - Features of hypoglycemia in insulinoma patients investigated
Legal Issues - Urologist sentenced for healthcare fraud
Leukemia - Findings in leukemia provide new insights
Leukemia - Generic drug company, Gamida-Cell to develop StemEx for treatment of leukemia
Leukemia - Genome-wide mouse study yields link to human leukemia
Leukemia - Plant derivative attacks the roots of leukemia
Leukemia - Protein that helps stem cells may be key to poor leukemia prognosis
Licensing - Vertex Pharma licenses VX-944 to Avalon Pharma for cancer treatment
Liver Cancer - Color Doppler ultrasound monitors the efficacy of occlusive tumor therapy
Liver Cancer - Inoperable liver cancer BrachySil trial shows positive results
Liver Cancer - JVIR article highlights Theraspheres liver cancer treatment
Liver Cancer - Nanotech company reports positive phase 2a trial results in liver cancer
Lung Cancer - Cytotoxic effects of 8-chloro-adenosine elucidated
Lung Cancer - Research uncovers mechanism of resistance to targeted therapy
Lymphedema - Lymphedema of the arm can cause traumatic shoulder injury
Malaria - Biotechnology company buys rights to Tetrandrine
Medullary Thyroid Cancer - Anti-CEA antibody labetuzumab shows promise for treatment
Mesenchymal Tumors - Nuclear beta-catenin staining useful in diagnosis
Metastatic Melanoma - Biopharma company announces results in talabostat metastatic melanoma study
Natural Products - The herb Rabdosia rubescens halts breast cancer growth and angiogenesis
Non-Hodgkin Lymphoma - Findings in non-hodgkin lymphoma provide new insights
Non-Small Cell Lung Cancer - Gene expression alterations in squamous NSCLCs identified
Oncology - Angiogenesis and lymphangiogenesis rank breast cancer metastasis risk
Oncology - Antisense CK2 causes prostate cancer cells to self-destruct
Oncology - COX-2 drives a VEGF-C-related lymphangiogenic pathway in head and neck cancer
Oncology - CagA structure variability may explain H. pylori-related diseases
Oncology - Complement-independent mechanisms support neoplastic progression
Oncology - CpG oligonucleotide and rituximab combine to attack non-Hodgkin lymphoma
Oncology - Ellagic acid limits angiogenic stimulation and tumor proliferation
Oncology - Gene sets identify hepatitis B virus-related liver cancer
Oncology - Gene silencing curbs the growth of breast cancer cells
Oncology - Genomic stability of post-resection lung cancer specimens determined
Oncology - Reports add new data to oncology research
Oncology - Ribavirin interrupts oncogenesis by impeding translation initiation factor
Oncology - Tetrandrine suppresses pulmonary metastasis in rodent colorectal cancer models
Oncology - Tumors flourish in the presence of von Hippel-Lindau inactivation
Oncology - Vascular leukocytes support tumor vessel growth
Ovarian Cancer - LPA induces IL-6 expression via a Gi/PI3K-Akt/NF-kappaB pathway in cancer cells
Ovarian Cancer - Researchers further evaluate OvaRex Mab for ovarian cancer
Palliative Care - Palliative care questions unlikely to cause distress for family members
Palliative Sedation - Study examines family experience during palliative sedation in cancer patients
Pancreatic Cancer - IFN-gamma polymorphisms correlate with duration of survival in pancreatic cancer
Pancreatic Cancer - Trial of pancreatic cancer did not meet primary endpoint
Patents - Healthcare technology company issued patent for early cancer detection product
Personnel - Biopharmaceutical company adds to board of directors
Personnel - Biopharmaceutical company names chief scientific officer, chief medical officer
Personnel - Biotechnology company hires non executive director
Personnel - Jean-Yves Bonnefoy named chief scientific officer by biopharmaceutical company
Personnel - Medical manufacturer names vice president and medical director
Personnel - Pharmaceutical company adds to scientific resource board
Personnel - Pharmaceutical company names new chief financial officer
Product Licensing - Pharmaceutical company licenses topical products for hair growth
Product Licensing - Soy isoflavones patent rights transferred to Archer Daniels Midland
Prostate Cancer - Baicalein limits prostate cancer cell growth in mice
Prostate Cancer - Data: Provenge significantly improves survival in advanced prostate cancer
Prostate Cancer - Dual targeting of HER-2 and EGFR not recommended
Prostate Cancer - Injectable hormonal therapy for advanced prostate cancer available in the U.S.
Prostate Cancer - New diagnostic test kit for prostate cancer released
Prostate Cancer - Phase 2 monotherapy trial of polyketide treatment for prostate cancer initiated
Prostate Cancer - Researchers report on palliative care principles, practice in prostate cancer
Prostate Cancer - Studies advance knowledge in prostate cancer research
Proteomics - Altered cellular signals augment RNA interference in neuroblastoma cells
Proteomics - Angiostatin fragment blocks cancer cell metastasis
Pulmonary Botryomycosis - Researchers report on case of primary pulmonary botryomycosis
Retinoblastoma - Symposium to focus on latest developments in retinoblastoma research, treatment
Sacrococcygeal Teratoma - LigaSure vessel sealing system useful in removing highly vascular tumor
Stem Cell Research - Letter of Intent filed with U.S. NIH for stem cell research center grant
Stem Cell Transplantation - Findings advance knowledge in stem cell transplantation research
Surgical Technology - Quantix/OR blood flow measurement 510k accepted by U.S. FDA
Testicular Cancer - NALP7 may be therapeutic target in testicular seminomas
Thyroglossal Duct Lesions - Thyroglossal duct lesions misdiagnosed in pediatric patients in Nigeria
Tissue Engineering - MSCs immunoprivileged & potentially useful for HLA-incompatible transplantation
Tissue Engineering - Osteochondritis dissecans of talus treated with tissue-engineered cartilage
Umbilical Cord Blood Transplantation - Umbilical cord stromal cells promising for cell-based therapies
Uterine Cancer - Most minimal uterine serous carcinomas involve an endometrial polyp
Uterine Fibroids - ExAblate 2000 System recognized by Advanced Imaging magazine
Vaccine Development - DNA vaccine targeting survivin eradicates lung tumor growth and metastasis
Vector Development - Viral vector follows anti-mesothelin antibody to ovarian cancer cells
Virology - Multi-mutated herpes simplex virus curtails tumor angiogenesis
Virology - Semliki Forest virus vector battles fast growing murine tumors
Water Treatment - Coagulation pretreatment influences protozoan cyst removal from water
Wilms Tumor - Adult nephroblastoma patients may carry WT1 germline mutations
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