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Clinical Oncology Week

Susan Hasty, Publisher

Table of Contents . . . March 14th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Clinical Oncology Week | Other Publications

Cancer Diagnostics - Markers distinguish primary ovarian tumors from metastatic colorectal cancer

Cancer Risk Factors - Obesity associated with progression of prostate and renal cell cancer

Chemotherapy - Most concerns of female cancer patients aren't identified by nurses

Lung Cancer Therapy - Docetaxel approved for treatment of advanced non-small-cell lung cancer

Pituitary Cancer - Transsphenoidal surgery effective for secreting pituitary tumors

Allergy and Immunology - Local gene therapy can help dendritic cells fight tumor growth

Allergy and Immunology - Thymalfasin shows promise for treating viral hepatitis and cancer

Alzheimer Disease - Phase 2 clinical study for Alzheimer disease completed

B-Cell Lymphoma - Flow cytometry useful for detection of occult CSF involvement

Biomedical Engineering - Biotechnology company reports progress in avian transgenics biomanufacturing

Biomedical Engineering - Interleukin-12 fusion protein and homing peptide eradicate neuroblastoma

Cancer Genetics - Researchers report details of new studies and findings in the area of cancer genetics

Bioterrorism - Company initiates animal studies on compound to treat exposure to terror weapons

Bladder Cancer - Dietary carotenoids and genetic instability modify bladder cancer risk

Bladder Cancer - HER3 and HER4 expression associated with better survival in bladder cancer

Brain Cancer - Proton magnetic resonance spectroscopic imaging provides pediatric biomarkers

Brain Tumor - Treatment for brain tumors granted orphan designation in Japan

Breast Cancer - Breast cancer foundation hosted annual conference

Leukemia - Recent findings in leukemia provide new insights

Breast Cancer - Candidate genes in breast tumors identified through matrix-CGH analysis

Breast Cancer - Colorado imaging group offers MRI scanning for breast cancer detection

Breast Cancer - Endothelin-1 increases breast tumor perfusion in rats

Breast Cancer - Entities collaborate to analyze DNA samples from breast cancer patients

Breast Cancer - FAK upregulation in ductal carcinoma in situ is early event in tumorigenesis

Breast Cancer - Investigator-sponsored phase 1 trial data of breast cancer treatment presented

Oncology - Reports advance knowledge in oncology research

Breast Cancer - New MRI-based imaging method may improve breast cancer detection

Breast Cancer - Nucleolar size and activity related to pRb, p53 status in human breast cancer

Breast Cancer - Studies describe new findings in breast cancer research

Breast Cancer - Survey finds women will be inconvenienced for noninvasive biopsy procedures

Breast Cancer Risk Factors - Integrin beta(3) Leu33Pro polymorphism may increase breast cancer risk by age 45

Business & Finance - DNA-focused biopharmaceutical company announces fourth quarter, year end results

Business Update - Company to expand Cesium-131 production through leased new facility

Business Update - Sales accountability company teams with medical device manufacturer

Cancer Genetics - Researchers publish new studies and findings in the area of cancer genetics

Cancer Metastasis - Cervical node lesions and inflammatory changes look similar on ultrasound

Cancer Metastasis - Tight junction protein levels decline in metastatic breast cancers

Cancer Screening - Model predicts live-saving benefits of different mammography schedules

Cancer Therapy - Akt activation can promote resistance to microtubule-directed agents

Cancer Therapy - Caveolin gene delivery diminishes tumor angiogenesis by targeting nitric oxide

Cancer Therapy - Liposome-encapsulated lipophilic gemcitabine prodrugs synthesized

Cancer Therapy - Novel breast cancer cell line may aid research on trastuzumab resistance

Cancer Therapy - Strategies to disrupt anti-apoptosis protein must overcome major hurdles

Cancer Therapy - Tyrosine kinase inhibitors disrupt malignant mesothelioma growth factors

Cardiovascular Disease - There is a potentially profound overlap between CV conditions and cancer

Cell Biology - CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide

Cell Biology - Research reveals insights into how oncogenic protein regulates cell growth

Chronic Liver Disease - Protein profiles find cancer markers in patients with chronic liver disease

Chronic Lymphocytic Leukemia - Paper published in immunology journal describes action of T cell product in CLL

Chronic Lymphocytic Leukemia - Safety and efficacy of cladribine in CLL treatment clarified

Coccidian Parasite -  C. cayetanensis important parasite in immunocompromised persons

Collaborations - First groundbreaking held in U of California San Diego Science Research Park

Collaborations - Hospital and university partner to develop health service and education programs

Collaborations - Platinum IV compound licensed from M.D. Anderson Cancer Center

Colon Cancer - Age-related ERRP loss in aging colon is potential risk factor for colon cancer

Colon Cancer - Ring finger protein 43 may be novel immunotherapy target

Colon Cancer - Tumor proteins linked to C225 resistance identified

Colorectal Cancer - Patient enrollment completed for HGS-ETR1 phase II trial in colorectal cancer

Coronary Artery Disease - A high percent of CAD/MI population may carry mutations in MEF2A

Cutaneous T Cell Lymphoma - HuMax-CD4 shows encouraging duration of response data in T cell lymphoma

Diagnostics - Arginine-arginine-leucine augments tumor vessel imaging

Diagnostics - Assays used to identify potential treatments for drug-resistant strain of HIV

Diagnostics - Elispot assay optimized to detect cytomegalovirus-specific CD8+ T lymphocytes

Diagnostics - Test to check for bladder cancer more reliable than cystoscopy, study shows

Diet & Nutrition - Biotech company enters alliance to launch Resurgex and Resurgex-Plus

Drug Delivery - Novel norcantharidin microemulsions formulated for parenteral use

Drug Development - Cobalamin-colchicine conjugate shows promise as tumor-targeted cytotoxin

Drug Development - Lipid methotrexate derivative synthesized

Drug Development - Novel retinoic acid metabolism blocking agents have antitumor activity

Emergency Medicine - Ruptured gastrointestinal stromal tumor mimics acute appendicitis

End-of-Life Care - Referrals to palliative care come too late to improve life for cancer patients

Epidemiology - Recent studies add new data to epidemiology research

Epidemiology - Water is a major vehicle for Cryptosporidium transmission

Esophageal Cancer - Genes linked to esophageal squamous cell carcinogenesis identified

Finance - Cardiovascular therapeutics company reports second quarter fiscal 2005 results

Finance - Diagnostics company reports quarterly, year-end financial results

Finance - Fine chemicals manufacturer reports third quarter fiscal 2005 results

Finance - Radiation therapy company reports strong fourth quarter results

Gastric Cancer - Obesity increases risk of gastrointestinal malignancies

Gene Research - CuraGen exercises option to expand antibody-drug conjugate collaboration

Gene Research - Separating chromosomes may improve genetic test results, study shows

Genotoxicity - Multiple factors contribute to mechanism of particulate matter genotoxicity

Glioma - Drug in trials to treat glioma obtains orphan drug designation in Japan

Gynecology - Adeno-associated virus vector transmits therapeutic ligand to ovarian cancer

HIV/AIDS Diagnostics - BM biopsy not sensitive as diagnostic tool in AIDS patients with fever

Hairy Cell Leukemia - Rituximab may be effective as salvage therapy for Japanese variant HCL

Head and Neck Cancer - Cyclin D1 overexpression alone does not cause salivary gland cancer growth

Hepatitis C - Association noted between certain nonliver cancers and hepatitis C in Sweden

Hepatitis C Therapy - Drug development companies to codevelop recombinant human alfa interferon

Hepatocellular Carcinoma - DNA repair genes upregulated in cancer-related cirrhosis

Hypertension - Essential hypertension may be mildly influenced by the MTHFR C677T variant

Information Technology - Hospital physicians utilize information technology to improve patient care

Information Technology - New York hospital selects emergency department information management system

Information Technology - Pen-and-paper technology that transforms writing into digital text introduced

Insulinoma - Features of hypoglycemia in insulinoma patients investigated

Legal Issues - Urologist sentenced for healthcare fraud

Leukemia - Findings in leukemia provide new insights

Leukemia - Generic drug company, Gamida-Cell to develop StemEx for treatment of leukemia

Leukemia - Genome-wide mouse study yields link to human leukemia

Leukemia - Plant derivative attacks the roots of leukemia

Leukemia - Protein that helps stem cells may be key to poor leukemia prognosis

Licensing - Vertex Pharma licenses VX-944 to Avalon Pharma for cancer treatment

Liver Cancer - Color Doppler ultrasound monitors the efficacy of occlusive tumor therapy

Liver Cancer - Inoperable liver cancer BrachySil trial shows positive results

Liver Cancer - JVIR article highlights Theraspheres liver cancer treatment

Liver Cancer - Nanotech company reports positive phase 2a trial results in liver cancer

Lung Cancer - Cytotoxic effects of 8-chloro-adenosine elucidated

Lung Cancer - Research uncovers mechanism of resistance to targeted therapy

Lymphedema - Lymphedema of the arm can cause traumatic shoulder injury

Malaria - Biotechnology company buys rights to Tetrandrine

Medullary Thyroid Cancer - Anti-CEA antibody labetuzumab shows promise for treatment

Mesenchymal Tumors - Nuclear beta-catenin staining useful in diagnosis

Metastatic Melanoma - Biopharma company announces results in talabostat metastatic melanoma study

Natural Products - The herb Rabdosia rubescens halts breast cancer growth and angiogenesis

Non-Hodgkin Lymphoma - Findings in non-hodgkin lymphoma provide new insights

Non-Small Cell Lung Cancer - Gene expression alterations in squamous NSCLCs identified

Oncology - Angiogenesis and lymphangiogenesis rank breast cancer metastasis risk

Oncology - Antisense CK2 causes prostate cancer cells to self-destruct

Oncology - COX-2 drives a VEGF-C-related lymphangiogenic pathway in head and neck cancer

Oncology - CagA structure variability may explain H. pylori-related diseases

Oncology - Complement-independent mechanisms support neoplastic progression

Oncology - CpG oligonucleotide and rituximab combine to attack non-Hodgkin lymphoma

Oncology - Ellagic acid limits angiogenic stimulation and tumor proliferation

Oncology - Gene sets identify hepatitis B virus-related liver cancer

Oncology - Gene silencing curbs the growth of breast cancer cells

Oncology - Genomic stability of post-resection lung cancer specimens determined

Oncology - Reports add new data to oncology research

Oncology - Ribavirin interrupts oncogenesis by impeding translation initiation factor

Oncology - Tetrandrine suppresses pulmonary metastasis in rodent colorectal cancer models

Oncology - Tumors flourish in the presence of von Hippel-Lindau inactivation

Oncology - Vascular leukocytes support tumor vessel growth

Ovarian Cancer - LPA induces IL-6 expression via a Gi/PI3K-Akt/NF-kappaB pathway in cancer cells

Ovarian Cancer - Researchers further evaluate OvaRex Mab for ovarian cancer

Palliative Care - Palliative care questions unlikely to cause distress for family members

Palliative Sedation - Study examines family experience during palliative sedation in cancer patients

Pancreatic Cancer - IFN-gamma polymorphisms correlate with duration of survival in pancreatic cancer

Pancreatic Cancer - Trial of pancreatic cancer did not meet primary endpoint

Patents - Healthcare technology company issued patent for early cancer detection product

Personnel - Biopharmaceutical company adds to board of directors

Personnel - Biopharmaceutical company names chief scientific officer, chief medical officer

Personnel - Biotechnology company hires non executive director

Personnel - Jean-Yves Bonnefoy named chief scientific officer by biopharmaceutical company

Personnel - Medical manufacturer names vice president and medical director

Personnel - Pharmaceutical company adds to scientific resource board

Personnel - Pharmaceutical company names new chief financial officer

Product Licensing - Pharmaceutical company licenses topical products for hair growth

Product Licensing - Soy isoflavones patent rights transferred to Archer Daniels Midland

Prostate Cancer - Baicalein limits prostate cancer cell growth in mice

Prostate Cancer - Data: Provenge significantly improves survival in advanced prostate cancer

Prostate Cancer - Dual targeting of HER-2 and EGFR not recommended

Prostate Cancer - Injectable hormonal therapy for advanced prostate cancer available in the U.S.

Prostate Cancer - New diagnostic test kit for prostate cancer released

Prostate Cancer - Phase 2 monotherapy trial of polyketide treatment for prostate cancer initiated

Prostate Cancer - Researchers report on palliative care principles, practice in prostate cancer

Prostate Cancer - Studies advance knowledge in prostate cancer research

Proteomics - Altered cellular signals augment RNA interference in neuroblastoma cells

Proteomics - Angiostatin fragment blocks cancer cell metastasis

Pulmonary Botryomycosis - Researchers report on case of primary pulmonary botryomycosis

Retinoblastoma - Symposium to focus on latest developments in retinoblastoma research, treatment

Sacrococcygeal Teratoma - LigaSure vessel sealing system useful in removing highly vascular tumor

Stem Cell Research - Letter of Intent filed with U.S. NIH for stem cell research center grant

Stem Cell Transplantation - Findings advance knowledge in stem cell transplantation research

Surgical Technology - Quantix/OR blood flow measurement 510k accepted by U.S. FDA

Testicular Cancer - NALP7 may be therapeutic target in testicular seminomas

Thyroglossal Duct Lesions - Thyroglossal duct lesions misdiagnosed in pediatric patients in Nigeria

Tissue Engineering - MSCs immunoprivileged & potentially useful for HLA-incompatible transplantation

Tissue Engineering - Osteochondritis dissecans of talus treated with tissue-engineered cartilage

Umbilical Cord Blood Transplantation - Umbilical cord stromal cells promising for cell-based therapies

Uterine Cancer - Most minimal uterine serous carcinomas involve an endometrial polyp

Uterine Fibroids - ExAblate 2000 System recognized by Advanced Imaging magazine

Vaccine Development - DNA vaccine targeting survivin eradicates lung tumor growth and metastasis

Vector Development - Viral vector follows anti-mesothelin antibody to ovarian cancer cells

Virology - Multi-mutated herpes simplex virus curtails tumor angiogenesis

Virology - Semliki Forest virus vector battles fast growing murine tumors

Water Treatment - Coagulation pretreatment influences protozoan cyst removal from water

Wilms Tumor - Adult nephroblastoma patients may carry WT1 germline mutations

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