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Clinical Oncology Week

Susan Hasty, Publisher

Table of Contents . . . March 21st, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Clinical Oncology Week | Other Publications

Breast Cancer - Digital mammography shows lower percent breast density than analog images

Breast Cancer - MRI better than current standard in assessing neoadjuvant chemotherapy

Cancer Vaccines - PLGA microspheres improve antigen delivery to dendritic cells

Colon Cancer - Extracellular enzymes predict the outcome of colorectal cancer

Melanoma Vaccine - MAGE-A3 is a frequent tumor antigen of metastasized melanoma

Prostate Cancer - Immune-based therapies for prostate cancer reviewed

Actinic Keratosis - Applying fluorouracil cream before cryosurgery reduces AK lesions, study shows

Acute Intracerebral Hemorrhage - Journal publishes results of acute intracerebral hemorrhage study

Allergy and Immunology - Constructs with membrane bound or secreted GITR-L bypass immune suppression

Allergy and Immunology - Small molecule inhibitors suppress nanoparticle-mediated inflammatory response

Aspergillosis - EIA/qPCR used to diagnose invasive aspergillosis in high-risk patients

B-Cell Lymphoma - TCL1A overexpression linked to poor outcome in DLCL patients

Cancer Genetics - Recent findings illuminate research in cancer genetics

Bone Cancer - Cryosurgery results comparable to those of marginal excision

Brain Cancer - New findings in the area of brain cancer detailed

Breast Cancer - Aromatase inhibitors may be more effective than antiestrogens for prevention

Breast Cancer - CAD detects small lesions radiologists are likely to miss

Breast Cancer - Cyclin D1 variant seems to reduce effect of hormonal exposure in older women

Breast Cancer - Cytotoxic mechanisms of 15dPG-J2 determined

Cancer Genetics - Researchers report details of new studies and findings in the area of cancer genetics

Breast Cancer - HER2 DNA delivered by adenoviral vector

Breast Cancer - High serum testosterone levels predict breast cancer recurrence

Breast Cancer - Higher cancer rates likely to accompany westernization of Singaporean lifestyle

Breast Cancer - IGF-I gene polymorphisms may be risk factor in Chinese women

Breast Cancer - Imaging system detects cancers missed by mammography

Breast Cancer - Increasing physician volume requirement could improve mammogram accuracy

Cancer Vaccines - Researchers' data advance cancer vaccines research

Breast Cancer - Intervention helps women treated for cancer make major dietary changes

Breast Cancer - Low serum HDL-C may be biomarker of cancer risk in overweight and obese women

Breast Cancer - MRI useful for assessing patients with suspected cancer

Breast Cancer - Masking of erbB2 may underlie Herceptin resistance

Breast Cancer - Older women can benefit from chemotherapy

Breast Cancer - Peptide assay variability in IGF-I-based risk estimates compared

Cancer Vaccines - Researchers' work adds to cancer vaccines body of knowledge

Breast Cancer - Positron emission mammography device detects small lesions

Breast Cancer - Recent findings in breast cancer described

Breast Cancer - Short course of hCG may have chemoprotective potential

Breast Cancer - Urinary estrogen metabolite ratio may signal higher risk in Asian Americans

Breast Cancer Risk Factors - Risk factors differ by age, race among African American and white women

Breast Cancer Vaccine - Killed Mycobacterium vaccae may augment efficacy of trastuzumab

Oncology - Researchers describe findings in oncology studies

Business & Finance - Drug discovery company announces financial results

Business & Finance - Research company reports preliminary fourth quarter and year-end results

Business Update - Biopharma company signs agreement with Celliance BioServices, Inc.

Business Update - Consulting company reports Medicare reform changing oncology practices

Business Update - Gene therapy company reports progress of avian transgenic biomanufacturing

Business Update - Pennsylvania center granted recertification by American College of Surgeons

Business Update - Pharma company engages WorldCare Clinical for diagnostic services

Business Update - Sentigen Holding Corp. Announces the Sale of Its Specialty Media Division

Cancer Diagnostics - Diagnostic products company files IND for biopsy product

Cancer Genetics - New data illuminates research in cancer genetics

Cancer Prevention - L-carnitine prevents liver cancer formation in laboratory models

Cancer Research - Reolysin clinical trial approved by U.K. regulatory authorities

Cancer Therapy - Antagonists to melanoma-inhibiting activity foil immunosuppression

Cancer Therapy - Chemists synthesize molecule that helps body battle cancers, malaria

Cancer Therapy - Findings advance knowledge in cancer therapy research

Cancer Therapy - Toll-like receptor 9 agonist enhances antitumor activity of Cetuximab, data show

Cancer Vaccines - Amino acid substitution improves enzymatic stability of MUC2 epitope

Cancer Vaccines - B-lymphocytes activated by CD40 ligand induce anti-tumor response

Cancer Vaccines - Findings describe new data in cancer vaccines research

Cancer Vaccines - IL-12-secreting dendritic cells generate anti-tumor immunity in mice

Cancer Vaccines - Immunotherapy for malignant gliomas reviewed

Cancer Vaccines - Multi-epitope vaccines elicit CD8+ cytotoxic T cells

Cancer Vaccines - TP-3 immunotoxins improve antitumor activity in mice with osteosarcoma

Cervical Cancer - IFN gamma gene variant is associated with individual disease susceptibility

Cervical Cancer - Researchers' work adds to cervical cancer body of knowledge

Clinical Trials - Biopharmaceutical company receives payment, moves antibody into clinical trials

Clinical Trials - Drug company to focus on developing cancer and infectious diseases products

Collaborations - Pharmaceutical companies enter biogeneric partnership

Colon Cancer - Duke develops new breed of viral vaccines to battle colon cancer

Colon Cancer - Nondegraded total RNA extracted from colonocytes from normal/malignant tissue

Colon Cancer - Oral chemotherapy gets positive EU review for colon cancer after surgery

Colon Cancer - Osteopontin promotes tumor progression in multiple ways

Colon Cancer Risk Factors - Dietary calcium linked to reduced risk of colorectal cancer in women

Colorectal Cancer - Noninvasive early stage colorectal cancer diagnostic test being developed

Colorectal Cancer - Novel purification method improves DNA yield from stool

Colorectal Cancer - Research company awarded grant to study DNA mutations in colorectal cancer

Colorectal Carcinoma - Microsatellite-stable, near-diploid bowel tumors characterized with array-CGH

Complementary & Alternative Medicine - Ursodiol may prevent cancer in those with hepatitis C-linked liver cirrhosis

Congenital Heart Disease - ENU-induced mutations may yield insights into genetic basis of CHD

Cystic Fibrosis - Therapeutic company receives $1.7 million award from cystic fibrosis foundation

Disease Associations - Bone density not related to breast density or risk of breast cancer

Drug Development - Modified heparin antagonizes angiogenesis without affecting coagulation

Drug Development - Pharmaceutical company files ANDA with U.S. FDA for opthalmic product

Drug Development - Somatostatin agonists may control tumor neovascularization

Electronic Medical Records - IT company makes mammography repository available on line directly to women

Endometrial Cancer Risk Factors - Tamoxifen use past 5 years is associated with increased endometrial cancer risk

Endometrial Carcinoma - Tissue microarray used to identify cancer-testis antigens

Enzymology - Cyclooxygenase-2 inhibition has a selective effect on endothelial cell growth

Enzymology - Matrix metalloproteinase inhibitor MMI270 helps chemotherapy fight metastasis

Esophageal Cancer - Premature birth significantly increases risk of GI cancer

Finance - Biotechnology company reports 2004 annual financial results

Finance - Cancer-focused bioscience company reports 2004 Q4 and year-end financial results

Finance - Cancer-focused pharmaceutical company reports Q4, full year 2004 results

Finance - Developer, manufacturer of human cell lines reports 2004 results

Finance - Healthcare company reports financial results for fourth quarter, year-end

Finance - Infection- and cancer-focused company reports year end 2004 financial results

Finance - Medical company allocates money to venture capital fund, changes personnel

Finance - Pharma company announces record financial results

Finance - Pharma company releases financial results showing increase in net income

Finance - Pharmaceutical company receives $750,000 equity investment

Finance - RNA-focused biotech company reports Q4 and full-year financial results

Finance - Vaccine-focused biopharmaceutical company announces FY 2004 financial results

Fungal Therapy - Profile of an ideal antifungal presented

Gastroenterology - Hepatitis C virus core protein alters liver cells differentially

Gastroenterology - TRAIL gene transfer keeps pancreatic tumors from growing in murine livers

Gastrointestinal Cancer - Overweight women with esophageal and stomach cancer survive longer

Gene Research - Circulating blood endothelial cells mark the efforts of antiangiogenic drugs

Gene Research - Controlled conditions allow laboratories to conduct collaborative gene studies

Gene Sequencing - NCI creates gene expression database of normal human organ tissue

Gene Transfer - New data illuminates research in gene transfer

Grants - $300,000 in unrestricted development grants given to 6 orthopedic surgeons

Grants - Cancer foundation sees 25% increase in grant applications, will pick 15 scholars

Gynecology - Molecular markers indicate the presence of cervical cancer

Gynecology - Researchers describe findings in gynecology studies

HIV/AIDS-Associated Infection - Severe respiratory disease necessitating hospitalization decreased in HAART era

Head and Neck Cancer - Antisense down-regulation of metallothionein-2A limits nasopharyngeal cancer

Healthcare Access - Cancer center developer changes name to Aptium Oncology

Healthcare Access - Women in poor neighborhoods tend to get late-stage cancer diagnosis

Hematology - Immature dendritic cells help CD40 ligand regress established myeloma

Hospice - Forgoing of end-of-life treatment varies in European countries

Human Papillomavirus - Prevalence of human papillomavirus genotypes in women reported

Human Papillomavirus Vaccine - Human papillomavirus oncoprotein vaccine eradicates established tumors

Imaging - Technology company receives approval to expand use of ImageChecker D product

Influenza Vaccine - Guide for flu and pneumococcal vaccines in cancer patients released

Licensing - Pharmaceutical firm acquires license to endothelinB agonists for chemo delivery

Liver Cancer - MRI suitable for assessment of internal radiation therapy

Liver Cancer - Nanotech company researcher explains clinical trials for liver cancer treatment

Lung Cancer - Mutated genes involved in lung cancer; one affects nonsmokers

Lung Cancer - Researchers learn why some lung cancers stop responding to erlotinib, gefitinib

Malignant Mesothelioma - Mesothelial marker D2-40 may be useful in differential diagnosis

Mammography Diagnostics - Mammography screening nonattenders in Denmark don't seek screening elsewhere

Melanoma - Doctors use sound to battle skin cancer

Melanoma Vaccine - Peptide vaccine has minimal benefit in patients with stage IV melanoma

Melanoma Vaccines - Findings advance knowledge in melanoma vaccines research

Mergers & Acquisitions - Pharma company to acquire Idun Pharmaceuticals

Myeloma - "Smart" immune cells kill more cancer

Nanotechnology - Industry consultancy releases two white papers on nanotechnology

Non-Hodgkin Lymphoma - Enrollment, initial dosing completed in HGS-ETR1 trial in non-Hodgkin lymphoma

Non-Hodgkin Lymphoma - Yttrium 90 ibritumomab tiuxetan does not impair subsequent treatment

Non-Small Cell Lung Cancer - Female sex is independent positive predictor of long-term postsurgery survival

Non-Small Cell Lung Cancer - Gene profiling can predict gefitinib susceptibility of NSCLC cells

Oncogenesis - Negative LMO2 gene regulatory elements may produce its appearance in leukemia

Oncology - Antiangiogenic gene therapy may be a valuable adjuvant for chemotherapy

Oncology - Antiangiogenic genes prevent secondary metastasis after primary tumor removal

Oncology - CXCR4 knockdown slows breast tumor growth and invasion

Oncology - Gene silencing sensitizes prostate cancer to cancer therapy

Oncology - Immunocompetent breast cancer models test Eph receptor-targeted therapy

Oncology - Orally administered bacteria transport anticancer genes in mice

Oncology - Protein antagonists reduce the metastatic potential of melanoma

Oncology - Recent findings illuminate research in oncology

Oncology - Research: Chemically induced breast cancers can be stopped by nutrients

Oncology - Small study finds total laparoscopic hysterectomy safe for morbidly obese women

Oncology - Utility of cancer screening tests reviewed

Oncology - Virally mediated Skp-2 RNA interference cuts cancer growth

Osteosarcoma - Gene amplifications identified through CGH microarray analysis

Ovarian Cancer - ApoE required for cell proliferation, survival in apoE-expressing cancer cells

Ovarian Cancer - Class III beta-tubulin overexpression a key mechanism of paclitaxel resistance

Ovarian Cancer - H-1-NMR-based metabonomics distinguishes patients from healthy controls

Ovarian Cancer - Intraperitoneal continuous hyperthermic chemotherapy is promising

Ovarian Cancer - New medicine may help patients with advanced ovarian cancer

Pain Management - New patch for treatment of chronic pain launched

Pancreatic Cancer - U.S. FDA clears randomized portion of phase II TNFerade in pancreatic cancer

Patents - Pharma company announces new patents

Patents - RNA-focused company granted 2 RNAi technology patents by U.K. Patent Office

Patents - U.S. patent granted for cyclin dependent kinase inhibitor series

Personnel - Healthcare company names Gary Klinefelter VP, general counsel, 3 others to team

Personnel - Immunotherapeutics company appoints board chairman

Personnel - John C. Schafer, Robert J. Deluccia named to pharmaceutical company posts

Personnel - Nevada cancer institute names VP of communications and public affairs

Personnel - Viral disease-focused company reports resignation of VP of medical affairs

Pharmaceutical Research - Study focusing on EU pharma and biotech growth opportunities released

Pharmaceutical Research - U of Maryland faculty awarded $3.2 million to develop technology products

Philanthropy - Genomics-focused biomedical company foundation announces new charitable fund

Philanthropy - Kleberg Foundation gives $5 million to M.D. Anderson for molecular marker center

Platelets - Enhanced platelet activation occurs in colorectal cancer patients

Polyphenols - Special issue offers overview of evidence of effects of polyphenols on health

Product Licensing - Pharma company licenses novel anticancer compounds

Prostate Cancer - 3alpha-diol stimulates prostate cell proliferation via EGF-like pathway

Prostate Cancer - Analysis shows drug could save men's lives

Prostate Cancer - CB7630 phase I clinical data presented at prostate cancer meeting

Prostate Cancer - Celecoxib provides double prostate cancer cell proliferation

Prostate Cancer - Pharmaceutical company announces results of prostate cancer clinical trial

Prostate Cancer - Provenge/Avastin combo increases PSADT

Prostate Cancer - U.S. FDA approves new device for diagnosing and treating prostate cancer

Prostate Cancer Therapy - Phosphoglycerate mutase B is molecular target of resveratrol

Prostate Cancer Vaccines - Researchers' findings advance prostate cancer vaccines research

Psoriasis - Research company reports efficacy and safety results of psoriasis treatment

Reproductive Medicine - Ovarian reserve testing in cancer patients needs more study for clinical use

Resveratrol - Resveratrol's cancer prevention may result from changes in cell cycle progress

Skin Cancer - Recent studies add new data to skin cancer research

Stem Cell Transplantation - Alternate hemibody irradiation + HD chemotherapy treats hematological malignancy

Stem Cell Transplantation - Five-year survival >80% after HSCT with matched unrelated donors

Stem Cell Transplantation - Reconstitution of CMV-specific CD8+ T cells delayed after SCT

Stem Cells - Study finds hematopoietic stem cells depend on a single protein Mcl-1

Stroke - MTHFR allele evaluation will help prevent/reduce morbidity caused by stroke

Surgical Technology - Health system adds radiosurgery technology

Tobacco Use - First global anti-smoking treaty becomes binding international law

Umbilical Cord Blood Transplantation - CBT treats case of EBV-related lymphoproliferative disease

Vaccine Development - Toll-like receptors induce antigen cross-presentation

Virology - Research add new data to virology body of knowledge

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