Human Papillomavirus

Epitope specificity of vaccine-induced T cell response against HPV18 reported

Published in Clinical Oncology Week, April 4th, 2005

Researchers have determined the epitope specificity and longevity of a vaccine-induced human T cell response against HPV18.

"Persistent human papillomavirus (HPV) type 16 and 18 infection can lead to pre-malignant and malignant diseases of the lower genital tract. Several lines of evidence suggest that T cell responses can control HPV infection. However, relative to other human viruses, strong effector memory T cell responses against HPV have been difficult to detect. We used an in vitro stimulation step prior to enzyme-linked immunospot assays to identify IFN-gamma-secreting T cells specific for HPV16 and 18 E6/E7 peptides. This allowed the detection of HPV-specific...

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Source: Clinical Oncology Week (2005-04-04)

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