Published in Clinical Oncology Week, April 4th, 2005
According to a study from the United States, "Knudson [Knudson AG, Proc Natl Acad Sci USA 1971;68:820-823] suggested that progression of retinoblastoma follows from two mutational events. Individuals who inherit one mutated gene copy should follow an age-onset pattern set by only a single rate-limiting step for transformation, whereas normal individuals should follow an age-onset pattern set by two rate-limiting events."
"Knudson's analysis of inherited and sporadic cases of retinoblastoma supported this prediction. However, retinoblastoma has a peculiar age-onset pattern...
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