Clinical Oncology Week
Susan Hasty, Publisher
Table of Contents . . . May 30th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Clinical Oncology Week | Other Publications
Leukemia - Efficacy of combining fludarabine with cyclophosphamide and mitoxantrone tested
Liver Cancer - Predictive value of CLIP, Okuda, TNM and JIS staging systems evaluated
Lung Cancer - Sleeve resection resulted in higher locoregional recurrence of lung cancer
Pediatric Cancer - High incidence of malformation syndromes correlated to pediatric cancer
Prostate Cancer - High dose rate (HDR) brachytherapy treated localized prostate cancer
Abdominal Cancer - Internal and externals markers correlated with abdominal tumor motion
Acute Myeloid Leukemia - RT-PCR is an early predictive factor of relapse risk in AML with t(8; 21)
Adenocarcinoma - Secondhand smoke induces adenocarcinoma via p16//DAPK/RASSFIA gene inactivation
Adrenocortical Carcinoma - HLA-DRB1* 01 genotype increases risk for adrenocortical carcinoma
Anticancer Effect - Cruciferous phytoalexin has antiproliferative activity
Antimicrobial Resistance - Antimicrobial resistance creates challenges when treating cancer/neutropenia
Breast Cancer - Findings advance knowledge in breast cancer research
Apoptosis - Apoptosis research company reports preclinical results of animal sepsis study
Apoptosis - NF-kappa B overrides apoptotic program of TNFr 1 but not CD40 in carcinoma cells
Astrocytoma - Human gliomas analyzed, differential protein expression revealed
Barrett Esophagus - limitations of therapies for dysplasia in Barrett esophagus presented
Basal Cell Cancer - Basal cell carcinoma developed following laser therapy for cutaneous lesions
Basal Cell Cancer - Basal cell carcinoma of nipple and areola reported in a 49-year-old woman
Breast Cancer - Reports advance knowledge in breast cancer research
Bioinformatics - Computer-aided image analysis quantifies tumor vascularity
Bioinformatics - Improved cancer treatments aim of new biology research program
Bladder Cancer - Multiple mechanisms downregulate CDKN1C in bladder cancer
Brain Cancer - Timing of examination affected reliability of differentiating brain hematomas
Brain Cancer - Valproic acid enhances brain tumor cell radiosensitivity
Breast Cancer - AMAP1 expression provides targets to inhibit breast cancer invasive activities
Cancer Therapy - Studies describe new findings in cancer therapy research
Breast Cancer - Aberrant HOX gene expression related to breast cancer development
Breast Cancer - Biopharmaceutical company licenses phase II clinical anticancer compound
Breast Cancer - Breast cancer recurrence and metastases analyzed with FDG-PET
Breast Cancer - CAD system makes breast MRI more effective, efficient
Breast Cancer - CAM use is associated with increased perception of cancer risk, death
Breast Cancer - Data advance knowledge in breast cancer research
Oncology - Recent findings illuminate research in oncology
Breast Cancer - ERBB2 variant Ile654Val associated with increased familial breast cancer risk
Breast Cancer - Electrical impedance findings strongly correlated with early cancer detection
Breast Cancer - Fine-needle aspiration should be first step in assessing suspicious lymph nodes
Breast Cancer - HIV Tat targeted into mitochondria of breast cancer cells
Breast Cancer - Imatinib mesylate monotherapy used to treat metastatic breast cancer
Oncology - Recent findings in oncology provide new insights
Breast Cancer - Interleukin-10 promoter polymorphism associated with lower breast cancer risk
Breast Cancer - Long-term results of lung density correction for radiation dosage presented
Breast Cancer - Lymphoedema, poor fitness related to upper-body disability following treatment
Breast Cancer - MAPH assesses genomic imbalances in malignant tissues
Breast Cancer - Makers of new blood test for breast cancer seeks future test candidates
Breast Cancer - Mammaglobin A is a promising marker for breast cancer
Oncology - Research in oncology provides new insights
Breast Cancer - Melatonin-estrogen interactions related to breast cancer
Breast Cancer - Modified antibody detects HER-2 over-expression in breast cancer
Breast Cancer - P16 and its cytoplasmic sequestration is a feature of breast carcinoma
Breast Cancer - Pivotal breast cancer study launched
Breast Cancer - Primary docetaxel chemotherapy in patients with breast cancer impacted survival
Breast Cancer - RAD21 supression decreases cell growth in breast cancer cells
Oncology - Researchers report details of new studies and findings in the area of oncology
Breast Cancer - Refeeding after chronic dietary energy restriction reverses anticancer effect
Breast Cancer - SPARC sways survival and tumor progression in breast cancer patients
Breast Cancer - Study findings suggest cancer etiology and outcome may be linked
Breast Cancer - Substantial 15-year survival gains from standard treatments
Breast Cancer - Survey shows communication trends between cancer survivors and health providers
Breast Cancer - Tamoxifen shows no benefit, risk for breast cancer survivors' heart health
Breast Cancer - The phyotochemical derivative DIM diminishes angiogenesis in breast tumors
Breast Cancer - Untreated low-grade ductal carcinoma in situ poses long-term risk
Breast Cancer - Valproic acid/RA/Aza-dC restores silenced RAR beta 2 expression in breast cancer
Breast Cancer Screening - Links between mammography access and breast cancer stage reported
Breast Cancer Therapy - Accuracy of 192Ir HDR breast brachytherapy dosimetry planning determined
Business & Finance - Biopharmaceutical company announces 2005 second quarter finances
Business & Finance - Cancer-focused biopharmaceutical company reports financial results for Q1 2005
Business & Finance - Cancer-focused pharmaceutical company reports Q1 2005 financial results
Business & Finance - Developer of protein-based diagnostic products reports first quarter finances
Business & Finance - Genetic and molecular diagnostic testing company announces financial results
Business & Finance - Melanoma-focused pharmaceutical company reports Q1 2005 financial results
Business & Finance - Pharmaceutical company reports financial results
Business & Finance - Pharmaceutical company reports first quarter 2005 financial results
Business Update - Cancer drug developer drops AS1405 to accelerate AS1411
Cancer Diagnosis - Gold nanoparticles may simplify cancer detection
Cancer Drugs - Alternating chemoreirradiation successfully treated head-and-neck cancer
Cancer Genetics - Factors affecting referrals to cancer genetic services in rural Wales examined
Cancer Immunotherapy - Complete immune depletion and stem cell transplantation stops cancer metastasis
Cancer Immunotherapy - Genetically modified lymphocytes recognize and kill human tumor cells
Cancer Immunotherapy - Treatment combining interleukin-2 and radiotherapy treats scalp angiosarcoma
Cancer Research - Published study characterizes mechanism of action of Xcytrin Injection
Cancer Risk Factors - New tumor suppressor gene linked to cancer predisposition
Cancer Screening - Breast CT reaches clinical testing, may improve on mammography
Cancer Therapy - All patients in phase III trial offered sorafenib for renal cell carcinoma
Cancer Therapy - Amplimexon exhibits unique mechanisms of synergy with gemcitabine
Cancer Therapy - Antineoplastic potential of TNF discussed
Cancer Therapy - Antitumor activity, lower toxicity reported with CoFactor combination therapies
Cancer Therapy - Continual progress in cancer research yields promising cancer therapies
Cancer Therapy - Copolymers synthesized as potential anticancer conjugates
Cancer Therapy - Data reported in study of doxorubicin in PLGA-based microparticles
Cancer Therapy - Depsipeptide makes cancer cells more vulnerable to TRAIL gene therapy
Cancer Therapy - Dual gene-virotherapy eradicates established tumors in animal models
Cancer Therapy - FDA accepts Genentech's application to start skin cancer treatment phase I trial
Cancer Therapy - Genomics company files IND application for HDAC inhibitor, CRA-024781
Cancer Therapy - Hormonal traits predict how well prostate cancer will respond to therapy
Cancer Therapy - IND filed with U.S. FDA to initiate trials of oral dosage form of AP23573
Cancer Therapy - Integrated approach identifies genes that determine cancer cell chemosensitivity
Cancer Therapy - NDA submitted to U.S. FDA for clinical trial of OncoVEX
Cancer Therapy - One-thousandth patient treated with BEBIG seeds
Cancer Therapy - Preliminary results for CoFactor phase II trial published
Cancer Therapy - Researchers' findings advance cancer therapy research
Cancer Therapy - Skin cancer treatments focus on surgical approaches, new noninvasive therapies
Cancer Therapy - Synergistic antitumor activity reported for GVAX cancer vaccine
Cancer Vaccines - Cancer immunotherapy targets minor histocompatibility antigens
Cancer Vaccines - Dendritic-cell-based therapeutic vaccination against cancer reviewed
Cancer Vaccines - Migration of dendritic-cell-based cancer vaccines reviewed
Cancer Vaccines - Native blood dendritic cells possess tumoricidal potential
Cancer Vaccines - Programming hematopoietic stem cells provides long-term T cell immunity
Cancer Vaccines - Role of CD4+ cells and antibodies in breast cancer protection described
Cancer Vaccines - Support for immunological mechanism of cancer vaccines research published
Cancer Vaccines - Tumor proteome suppressed by an adenovirus-based skin patch vaccine
Carcinoid - Treatments for carcinoid of the ampulla of Vater discussed
Cell Biology - Endothelial cell counter-receptor fosters CD97-induced angiogenesis
Cervical Cancer - Premanufacturing development announced for collector of cervical cell samples
Chemoradiation - Esophageal cancer patients treated with neoadjuvant chemoradiation reviewed
Chronic Myeloid Leukemia - p21(WAF)induction by 5-Aza-CdR leads to p53-independent apoptosis in CML
Colon Cancer - Behavioral risk factors for colon cancer defined
Colon Cancer - Better understanding of GI cancer drug may lead to improved Alzheimer treatment
Colon Cancer - Glutathione S-transferases associated with risk of developing colorectal cancer
Colon Cancer - IL-8 promotes cell proliferation in human colon carcinoma cells
Colon Cancer - Invasive colorectal cancers have classic gene expression profiles
Colon Cancer - Microsatellite instability in inflamed mucosa helped predict colonic neoplasms
Colon Cancer - Necrotic changes in metastatic lymph nodes linked to patient survival
Colon Cancer - Nonsteroidal anti-inflammatory drugs for colorectal cancer prevention advised
Colon Cancer - Subpopulation of T84 human colon cancer cells characterized
Colorectal Adenoma - PPARgamma Pro12Ala polymorphism may help protect against colorectal adenoma
Colorectal Cancer - Digital fecal occult blood test not suitable as primary screening test
Colorectal Cancer - Intestinal epithelial self-renewal rate reflects high malignant susceptibility
Colorectal Cancer - OcculTech fecal occult blood test suitable for colorectal neoplasia screening
Complementary and Alternative Medicine - Texas hospital announces collaboration with India yoga research institution
Diabetes Complications - Diabetic mastopathy can mimic cancer in women with type 2 diabetes
Diagnostics - Candidate proteins differentiate hepatitis B-related liver cancer
Drug Delivery - Cisplatin/adriamycin release from hydrogel has synergistic antitumor effects
Drug Development - Clofarabine approval highlights importance of giving children access to trials
Drug Development - IND submitted to U.S. FDA for trial of malignant melanoma therapy
Drug Development - Patient recruitment completed for AP 12009 phase II trial
Endocrinology - GH levels of patients with known pituitary tumors should be evaluated
Endocrinology - Parathyroid adenomas present unique gene expression profiles
Endocrinology - Reports describe recent advances in endocrinology research
Endocrinology - Surgical treatment of peritoneal carcinomatosis examined
Enzymology - Heparanase gene inhibition crushes melanoma cell invasion mechanisms
Epstein-Barr Virus - EBI3 may have role in regulating antiviral or antitumoral immune response
Esophageal Cancer - COX-2 inhibitor prevents esophageal inflammation-metaplasia-adenocarcinoma
Esophageal Cancer - Heavy exposure to free silica dust linked to esophageal cancer
Esophageal Leiomyoma - Local enucleation relieved symptoms in patients with esophageal leiomyoma
Finance - Biotech company focused on infectious disease, cancer reports Q1 2005 results
Finance - Cancer- and BPH-focused biotechnology company reports Q1 2005 financial results
Finance - Company focused on cell life raises $3.32 million in financing
Finance - Imaging systems company reports EPS of $0.02 in first quarter of 2005
Finance - Pharma company announces first quarter financial results
Flavonols - Flavonols increase nuclear ER protein/decrease ERalpha protein of osteoclast SCs
Gastric Cancer - H. pylori+enhanced mucosal IL-1beta production increases gastric cancer risk
Gastric Cancer - Bcl-2 gene activation implicated in aspirin-induced apoptosis in gastric cancer
Gastric Cancer - IL-8/IL-10/TNF-alpha polymorphisms associated with increased gastric cancer risk
Gastric Cancer - Prognostic factors of surgical resection in bile duct cancer examined
Gastroenterology - Gastrointestinal stromal tumor treated with imatinib
Gastroenterology - Researchers publish new studies and findings in the area of gastroenterology
Gene Research - Genetic polymorphisms modify breast cancer susceptibility in Korean women
Gene Transfer - Dominant-negative Epstein-Barr virus nuclear antigen 1 impairs cancer growth
Gene Transfer - SIRES bicistronic vectors enable clinicians to monitor therapeutic genes
Geriatrics - Partnership produces results of multi-center clinical trial
Graft-Versus-Host Disease - Extra-dornain-a fibronectin is a fibrosis marker in cutaneous GVHD
Gynecology - The CD109 gene is overexpressed in uterine cervix squamous cell carcinoma
HIV/AIDS Vaccines - Phase 1 trial of gene therapy treatment for HIV, plan for phase 2 study reported
Head & Neck Cancer - Hypoxia inducible factor levels correlate with esophageal cancer metastasis
Head & Neck Cancer - Interferon alfa-2a, isotretinoin, and vitamin E involved in phase 2 study
Head & Neck Cancer - Postradiotherapy QOL for head-and-neck cancer patients not linked to xerostomia
Head & Neck Cancer - Transverse cervical vessels used as recipient vessels in head and neck cancer
Healthcare Coverage - Insurance company introduces health portfolio
Hearing Disorders - Inner ear radiation and hearing loss occurred in head-and-neck cancer patients
Hematology - Cyclin B1 predicts favorable outcomes in patients with follicular lymphoma
Hepatitis C - New drug application for Tarvacin submitted to FDA
Human Papillomavirus - HPV 18 intratypic variants differentially associated with ADC and cervical SCC
Human Papillomavirus - High-risk mucosal HPV infections during infancy and childhood reviewed
Human Papillomavirus - Immune control of HPV-associated anogenital disease reviewed
Human Papillomavirus - Molecular diagnosis of human papillomavirus infections reviewed
Immunology - Unexpected lock and key found for the assembly of tumor blood vessels
Kaposi Sarcoma Marker - LANA sensitive/specific KS marker in general and HIV-infected populations
Kidney Cancer - Retroperitoneoscopic tumor ablation via ultrathin cryoprobes effective
Laryngeal Cancer - Helicoidal axial CT useful in staging anterior vocal commissure tumors
Leukemia - Causes of death in childhood acute lymphoblastic and myeloid leukemia defined
Leukemia - Genotypic and phenotypic characterization of Noonan syndrome conducted
Leukemia - How normal B cells become leukemic cells
Leukemia - Report of 17 cases treated with autologous or stem-cell transplantation examined
Leukemia - Reports describe recent advances in leukemia research
Leukemia - Researchers show new drug may help treat certain forms of leukemia
Leukemia - Response and resistance of leukemia to imatinib treatment evaluated
Leukemia - Significant reduction of hybrid BCR/ABL transcripts predicted treatment response
Liver Cancer - Clinicopathologic features of patients with malignant hepatic tumors compared
Liver Cancer - Risks of radiofrequency ablation for malignant liver tumors assessed
Lung Cancer - Angiogenesis biomarkers forecast non-small-cell lung cancer aggression
Lung Cancer - Cost-effectiveness of FDG-PET in lung cancer diagnostics analyzed
Lung Cancer - Diagnostic potential of promoter hypermethylation of CpG islands weighed
Lung Cancer - Different techniques used for urinary protein analysis of lung cancer patients
Lung Cancer - Fatty acid ratios manipulate cancer cell invasion through genetic regulation
Lung Cancer - Increased levels of urokinase plasminogen activator implicated in lung cancer
Lung Cancer - KLK5 and KLK7 differentially expressed in lung cancer
Lung Cancer - New therapeutic approaches for early stage non-small cell lung cancer discovered
Lung Cancer - P73 dinucleotide polymorphism associated with a reduced lung cancer risk
Lung Cancer - Recent findings in lung cancer described
Lymphoma - Clinical features and treatment outcome of NK/T cell lymphoma examined
Melanoma - Four different assays for the determination of serum S-100B compared
Melanoma Vaccine - Stat3 activity in melanoma cells affects NO-mediated antitumor effects
Menopause - Soy supplements don't improve symptoms in patients with early breast cancer
Mergers & Acquisitions - Cancer product development company completes acquisition of DELEX
Mergers & Acquisitions - Pharmaceutical and biotechnology companies sign letter of intent to merge
Mesotheliomas - Hyaluronan synthase expression marked pleural malignant mesotheliomas
Monoclonal Antibodies - Number of BAT/CD3 cells appear to vary by cancer type
Multiple Sclerosis - PharmaFrontiers selects CRO development partner for multiple sclerosis therapy
Natural Products - Shiraia bambusicola derivative is a potent angiogenesis inhibitor
Natural Products - Enzymatic pathways are conduits for apigenin-mediated antiangiogenesis
Neurofibromatosis - NF2 gene mutation detected in 100% of inherited cases via multiple techniques
Non-Small Cell Lung Cancer - Hospital and cancer institute grant rights to develop diagnostic test
Oncology - Cimetidine impairs angiogenesis to curtail tumor growth
Oncology - Delta Np73 antisense activates apoptosis in neuroblastoma cells
Oncology - Ellagic acid selects angiogenic cytokine receptors for inhibition
Oncology - Factors raise cancer risk in those with current and past HBV infections
Oncology - Fine-needle aspiration biopsy tumor samples suitable for microarray analysis
Oncology - Hepatitis B virus-related inflammation propagates mitochondrial loop mutations
Oncology - New findings in oncology described
Oncology - Oncolytic adenovirus-based antiangiogenic gene therapy attacks growing tumors
Oncology - Proteins that control angiogenesis increase before the advent of liver cancer
Ovarian Cancer - Blood test may detect deadly cancer in its early stages
Ovarian Cancer - Chemotherapy-induced nausea and vomiting affects women's choice of therapy
Ovarian Cancer - Increase in antibodies to MUC1 associated with reduced cancer risk
Ovarian Cancer - Recent findings in ovarian cancer described
Palliative Care - Oncologists advised to initiate talk of advance directive near end of life
Palliative Care - Outcome of palliative care and impact of attrition studied
Pancreatic Cancer - Combination treatment improves survival for pancreatic cancer
Pancreatic Cancer - Recent findings in pancreatic cancer provide new insights
Pancreatic Cancer - Supplemental new drug application filed for treatment of pancreatic cancer
Patents - International patents granted for Vitor
Pediatric Oncology - Antisense bcl-2 launches compensatory activity in neuroblastoma cells
Pediatric Oncology - Central venous catheter-related complications characterized
Pericarditis - CYFRA 21-1 and CEA assays diagnosed pericarditis
Personnel - Biotechnology company elects chairman of the board of directors
Personnel - Oncology corporation names chief development officer
Personnel - Robert L. Capizzi named chief medical officer, VP of life sciences company
Personnel - Zbigniew Wlwszek, PhD, appointed chief scientific officer of biotech company
Pharmaceuticals - Report shows pharma companies spend $76.8 million launching cancer treatments
Pheochromocytoma - Concentration of plasma-free metanephrines predicted tumor size and location
Prostate Cancer - Benign hyperplasia in the prostatic outer gland confused with prostate cancer
Prostate Cancer - Cancer researchers shake loose hidden biomarker
Prostate Cancer - Efficacy of androgen suppression in prostate cancer explored
Prostate Cancer - Gonadotropin-releasing hormone agonists treated localized prostate carcinoma
Prostate Cancer - New prostate cancer studies look at hormone and protein connection
Prostate Cancer - Pharmacokinetics of isotope-labeled antibody specific for PSA reported
Prostate Cancer - Secondary ellagic acid therapy in HRPC patients on standard chemotherapy tested
Prostate Cancer - Study shows how drug slows prostate-cancer growth
Proteomics - Hepatitis B virus X protein and hepsin interact to alter liver cell activity
Pulmonary Medicine - Amino acids make aerosolized gene delivery more robust
Pulmonary Medicine - PEI-plasmid DNA complexes stimulate minimal proinflammatory response
Pyothorax-Associated Lymphoma - ATM and ATR gene mutations have a role in pyothorax-associated lymphoma
Quality Assurance - New consensus ambulatory performance measures established by collaborative group
Radiation Therapy - Case of atypical teratoid/rhabdoid tumor reported
Radiation Therapy - Definition of biochemical failure after radiation therapy questioned
Rectal Cancer - Changes in metabolism of NAD/ADP-ribose in rectal cancer observed
Rectal Cancer - Preoperative staging offered high prognostic value in rectal cancer
Renal Cell Carcinoma - Companies report oral multi-kinase inhibitor accepted in FDA Pilot 1 Program
Retroviral Vectors - Chemotherapy augments gene therapy targeting tumor vessels
Sarcoma - Pilot study evaluated new chemotherapy regimen for children with metastatic STS
Skin Cancer - FDG PET compared with sentinel lymph node biopsy in squamous cell carcinoma
Skin Cancer - Fibroepithelioma of pinkus better described as fenestrated trichoblastoma
Skin Cancer - Low-dose retinoids prevented cutaneous SCC in organ transplant recipients
Skin Cancer - News coverage focusing on skin cancer prevention and detection found lacking
Skin Cancer - Survey finds majority of women still associate a tan with beauty and health
Skin Cancer - Women's group plans national sun safety program funded by 3M Foundation grant
Soft Tissue Sarcoma - RASSF1A inactivation is a common event in soft tissue sarcomas
Squamous Cancer - Distribution of cutaneous squamous cell carcinoma in organ transplant recipients
Stem Cell Transplantation - Studies advance knowledge in stem cell transplantation research
Supratentorial Glioblastoma - Temozolomide and cis-retinoic acid with radiation evaluated in phase II study
Telomerase - Telomerase inhibition via ribozyme targeting hTR inhibits breast cancer
Throat Cancer - Symptoms in patients with adenocarcinoma of the esophagus described
Thyroid Cancer - Novel genes identified in thyroid oncocytic adenomas
Thyroid Cancer - Valproic acid induces apoptosis in poorly differentiated thyroid cancer cells
Tumor Suppression - AP-1 dimers regulated transcription of p14/p19(ARF) tumor suppressor gene
Tumor Suppression - Cross-regulation between RUNX family members controls RUNX protein expression
Tumorigenesis - Hematopoietic cells regulate angiogenic switch during tumorigenesis
Vector Development - Research in vector development provides new insights
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