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Supratentorial Glioblastoma

Temozolomide and cis-retinoic acid with radiation evaluated in phase II study

Published in Clinical Oncology Week, May 30th, 2005

The efficacy of cis-retinoic acid (cRA) with temozolomide (TMZ) and radiotherapy has been evaluated in supratentorial glioblastoma patients.

Neuro-oncologists in the United States conducted a study "to determine the median survival time of adults with supratentorial glioblastoma treated with a combination" of TMZ and cRA "given daily with conventional radiation therapy (XRT)."

"This was a single arm, open-labeled, Phase II study," explained N. Butowski and coauthors at the University of California-San Francisco. "Patients were treated with XRT in conjunction with cRA and TMZ."

"Both drugs were administered starting on Day 1 of...

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