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Clinical Oncology Week

Susan Hasty, Publisher

Table of Contents . . . July 11th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Clinical Oncology Week | Other Publications

Brain Cancer - Adult growth hormone replacement therapy implemented in brain tumor survivors

Breast Cancer - Ablative therapies for treatment of malignant diseases of breast recommended

Chemoprevention - Acceptance of prophylactic surgery and chemoprevention surveyed in Singapore

Pancreatic Cancer - Carboplatin plus gemcitabine treated patients with metastatic pancreatic cancer

Prostate Cancer - Prostate cancer prevention proposed

Acute Myeloid Leukemia - Acute myeloid leukemia with complex aberrant karyotype profiled

Anal Cancer - Patterns of local disease failure and outcome after salvage surgery discussed

Androgen Receptors - Zinc finger protein TZF described as novel corepressor of androgen receptor

Aneuploidy Cancer - Aneuploidy linked to cancer development

Angiography - Risk analysis of magnetic resonance angiography for nonpalpable testis conducted

Antioxidants - In Summer's Heat, Hydrate the Healthy Way

Breast Cancer - Researchers' data advance breast cancer research

Apoptosis - Apoptosis in non-tumorous adult human testis tissue examined

Artificial Liver - HepG2/tk cells potential source for hybrid artificial liver support system

Avian Sarcoma Virus - Daxx interacts with ASV integrase and viral DNA to repress viral transcription

Bacteremia -  Streptococcus salivarius and Streptococcus bovis studied

Bladder Cancer - Accelerated radiotherapy for localized invasive bladder cancer studied

Bladder Cancer - Acute and late morbidity in treatment of bladder carcinoma evaluated

Breast Cancer - Studies describe new findings in breast cancer research

Bladder Cancer - Management of superficial bladder cancer in Victoria surveyed

Bladder Cancer - Terazosin limits vessel growth in transitional cell carcinoma of the bladder

Bleomycin - Role of intralesional bleomycin implicated in treatment of hemangiomas

Bone Cancer - Dedifferentiated parosteal osteosarcoma discussed

Bone Marrow - Bone marrow hyaluronan distribution correlated with acute myeloid leukemia

Bone Tumors - Chondromyxoid fibroma resembled in vitro chondrogenesis

Cancer Therapy - Research in cancer therapy provides new insights

Bone Tumors - Epidemiology and treatment strategy for bone and soft-tissue tumors reported

Brain Cancer - Topoisomerase II alpha linked to cell proliferation in brain tumors

Breast Cancer - Activated Akt expression in breast cancer correlated with patient outcome

Breast Cancer - Adjuvant docetaxel improves survival in women with node-positive disease

Breast Cancer - Bisphosphonates implicated in breast cancer treatment

Breast Cancer - Breast cancer diagnosis brought couples closer

Cancer Therapy - Researchers publish new studies and findings in the area of cancer therapy

Breast Cancer - Cadherin expression associated with breast cancer

Breast Cancer - Changes in gene expression associated with response to neoadjuvant chemotherapy

Breast Cancer - Circulating breast cancer tumor cells correlated to bone marrow micrometastases

Breast Cancer - Columnar cell lesions of the breast studied

Breast Cancer - Dietary flaxseed alters tumor biological markers in postmenopausal disease

Breast Cancer - Feasibility of low-dose multidetector dynamic CT in the breast evaluated

Colon Cancer - Researchers' findings advance colon cancer research

Breast Cancer - Findings describe new data in breast cancer research

Breast Cancer - Growth regulator holds promise for more targeted treatment

Breast Cancer - Learning curve guidelines modified for breast cancer sentinel node biopsy

Breast Cancer - Lobulitis frequently found in women at hereditary high risk of disease

Breast Cancer - MRI can help predict recurrence

Breast Cancer - Multiple re-excisions compared to mastectomy in breast cancer patients

Gastroenterology - Researchers report details of new studies and findings in the area of gastroenterology

Breast Cancer - New advances in breast cancer treatment presented at oncology meeting

Breast Cancer - New drug submission filed in Canada for metastatic breast cancer treatment

Breast Cancer - Prolonged skin staining after intradermal use of patent blue purported

Breast Cancer - Quality of life predicted in newly diagnosed melanoma and breast cancer patients

Breast Cancer - Second primary malignancies associated to breast cancer

Leukemia - Researchers detail new studies and findings in the area of leukemia

Breast Cancer Therapy - DNA methylation of PSAT1 determines response to tamoxifen treatment

Bronchoscopy - Bronchoscopy methods compared for detection of precancerous lesions

Business & Finance - Shareholder states intent to vote against $4.40 per share bid to acquire Corixa

Business Update - Louisiana hospital continues to outsource Trauma and Tumor Registry

Business Update - Oncology drug maker restructures business to focus on most advanced programs

Business Update - Pharmaceutical company's stockholders re-elect board of directors

Cancer Agenda - National agenda for Latino cancer prevention and control revealed

Cancer Detection - Tissue-specific marker mammaglobin may detect breast cancer metastasis

Cancer Drugs - Curcumin enhanced vinorelbine-mediated apoptosis in NSCLC cells

Cancer Genetics - New research in the area of cancer genetics detailed

Cancer Research - Origin of aberrant methylation in cancer cells traced

Cancer Research - Pharma company initiates Tarvacin phase I therapy clinical trial

Cancer Risk Factors - The c-MYC gene fuels prostatic carcinogenesis in murine models

Cancer Screening - Age and race/ethnicity are predictors of follow-up of ASCUS findings

Cancer Therapy - AGR2 may serve as a potential therapeutic target for prostate cancer

Cancer Therapy - Ablatherm HIFU a safe alternative to surgery or radiotherapy

Cancer Therapy - Non-toxic enzyme inhibitor thwarts experimental metastasis and angiogenesis

Cancer Therapy - Recent findings in cancer therapy provide new insights

Cancer Therapy - Use of HSV-1 as cancer therapy is limited by replication of the virus

Cancer Therapy - anti-Gal transduced tumor cells extend cancer vaccine protection

Cancer Vaccine - DNA vaccine plus IL-12 enhances anti-angiogenic and antitumor effects

Cancer Vaccine - Gene- and immunotherapy for hepatocellular carcinoma reviewed

Cancer Vaccine - IL-1 Trap Shows Positive Results in Study of Patients with Inflammatory Disease

Cancer Vaccine - New developments in dendritic cell-based vaccinations reviewed

Carcinogenesis - A region of human chromosome 4 is connected to cervical cancer formation

Carcinogenesis - Human homologue of maid is a useful marker protein in hepatocarcinogenesis

Cardiology - Computed tomography recommended for diagnosing intracardiac thrombi and tumors

Cell Transplants - Outcomes of ablative allogeneic hematopoietic cell transplantation in seniors

Cerebellar Injury - Existence of cerebellar cognitive affective syndrome evidenced

Cerebellar Lesions - Behavioral changes occurred in children with chronic cerebellar lesions

Cervical Cancer - Laparoscopic surgical staging performed for locally advanced cervical cancer

Cervical Cancer - Latinas in U.S. have higher disease incidence, but also higher survival rate

Cervical Cancer - Recent studies add new data to cervical cancer research

Cervical Cancer - Two L1-peptides help detect HPV-associated lesions

Chemotherapies - Adjuvant and neoadjuvant chemotherapy for bladder cancer studied

Chemotherapies - Advanced stage mucinous epithelial ovarian cancer studied

Choroidal Malignant Melanoma - Next-generation contrast agents improve echographic imaging

Cirrhosis - Nontyphoid Salmonella bacteremia detected in patients with liver cirrhosis

Cisplatin - Chemosensitivity of ovarian cancer tested via histoculture drug response assay

Clinical Trials - Bortezomib for injection showed positive activity across variety of lymphomas

Clinical Trials - Immunicon Corporation and Fox Chase Cancer Center Awarded NIH Grant

Clinical Trials - Pharma company presents diabetes drug candidates information at conference

Collaborations - Pharma companies announce antibody development agreement

Colon Cancer - Drug cocktail containing bevacizumab manages metastatic colorectal cancers

Colon Cancer - FDA approves oral Xeloda for the adjuvant treatment of colon cancer

Colon Cancer - Reports describe recent advances in colon cancer research

Colorectal Cancer - African-American screening rates higher in VA hospital

Colorectal Cancer - Clinical value of mitochondrial mutations in colorectal cancer examined

Colorectal Cancer - Colonoscopy performed 12 months after surgery for colorectal neoplasia

Colorectal Cancer - Efficacy of OCFL chemotherapy evaluated in metastatic colorectal cancer

Colorectal Cancer - Feasibility of sentinel lymph node biopsy in colorectal cancer examined

Contracted Bladder - Cystoprostatectomy and orthotopic ileal neobladder reconstruction discussed

Cryptosporidiosis - Cryptosporidiosis life threatening in transplant patients without antibiotics

Cushing Syndrome - Strategies for investigation and treatment of adrenal hyperplasia discussed

Cytokines - Cerebral output of cytokines found in patients with pneumococcal meningitis

DNA Research - Hydralazine demethylated and reactivated expression of tumor suppressor genes

Dermatology - Recent findings in dermatology provide new insights

Diagnosis - Delays in diagnosis of six cancers analyzed

Diagnosis - Reasons for delay in referral to specialist soft-tissue sarcoma unit determined

Diagnostic Imaging - Topographic 3D interstitial MDCT-LG navigates breast sentinel lymph nodes

Diagnostics - Accuracy and predictors of basal cell carcinoma evaluated

Diagnostics - Accuracy of image fusion using fixation device for cancer imaging was evaluated

Diagnostics - Cutaneous melanoma satellite lesions warrant sentinel lymph node biopsy

Diagnostics - Noninvasive colorectal cancer, polyp diagnostics technology using DNA available

Diagnostics - Reliable coding system for screening prostate-specific antigen tests developed

Diet & Nutrition - Sauerkraut is high-antioxidant cancer-fighting vegetable, Finnish study shows

Diet & Nutrition - Vitamin D receptor gene polymorphism linked to risk of prostate cancer in India

Drug Delivery - Bone-targeting macromolecular therapeutics discussed

Drug Development - Clofarabine active in a broad range of hematologic cancers

Drug Development - Company receives milestone payment for vaccine adjuvant

Drug Development - Data presented on anticancer activity of mycobacterial cell wall-DNA complex

Drug Development - Phase II trial of AS1404 in ovarian cancer initiated

Drug Development - U.S. FDA accepts proposal for rolling NDA for pancreatic cancer drug

Drug Development - U.S. FDA grants approval for carboplatin injection for cancer tumors

Drug Research - Antisense oligomer AVI-4126 has bioavailability in malignant tumors

Echocardiography - Rare case of large mediastinal germ cell tumor detected by echocardiography

Endocrinology - Carcinoid of the ampulla of Vater reported

Enzymology - Findings describe new data in enzymology research

Epstein-Barr Virus - Anti-latent membrane protein 2A antibodies detected in sera of patients

Esophageal Cancer - RhoA overexpression correlated with tumor progression in esophageal carcinoma

Finance - Isonics Extends the Expiration Date of its Class B and C Warrants One Year

Gallbladder - Chemical ablation of the gallbladder evaluated

Gastric Cancer - Gastric cancer lymph node status predicted by sentinel lymph node biopsy

Gastric Cancer - Perspectives in the treatment of gastric cancer discussed

Gastric Cancer - Researchers detail new studies and findings in the area of gastric cancer

Gastric Cancer - Tumor burden related to patients' minimization of distress in facing surgery

Gastroenterology - Clinical and biological overview of gastrointestinal stromal tumors performed

Gastroenterology - Molecular markers in aciner cells herald pancreatic cancer

Gastroenterology - Peripheral microvessel density underscores pancreatic cancer progression

Gastroenterology - Quality of life evaluated after thoracoabdominal esophageal resection

Gastroenterology - Researchers provide details of new studies and findings in the area of gastroenterology

Gene Profiles - Gene sets affiliate with malignant pleural mesothelioma

Genetics & Genomics - Chromosomal imbalances in retinoblastoma detected by genomic hybridization

Genital Tumors - Rare female genital tract tumor detected

Glioblastoma Multiforme - Temozolomid capsules approved in EU for treatment of glioblastoma multiforme

Gynecology - Cyclooxygenase-2 and iNOS combine to mark endometrial cancer angiogenesis

Gynecology - Neovaginal reconstruction needed after radical pelvic surgery

Gynecology - Pelvic exenterations performed for gynecological malignancies

Gynecology - Precolposcopic procedures do not change cervical tissue gene profiles

Gynecology - Risk factors listed for endometrial cancer recurrence

HIV/AIDS Drug Development - Cell-based protein translocation used to screen G protein-coupled receptors

HIV/AIDS-Related Cervical Cancer - Increased risk of preinvasive cervical lesions among HIV-infected women

Head & Neck Cancer - Squamous cell carcinoma treated with radiotherapy alone or combined with surgery

Head and Neck Radiotherapy - Dose enhancement effect of dental implants characterized

Hematopoietic Drugs - Hematopoietic progenitor cells mobilized by AMD3100

Hepatocellular Cancer - Elements predict the response of unresectable liver cancer to embolization

Hepatocellular Cancer - Proton beam therapy treated hepatocellular carcinoma

Hepatocellular Cancer - Survival after laparoscopic radiofrequency thermal ablation predicted

Hepatocellular Carcinoma - Novel arterial embolization technique effective for unresectable tumors

Herpesvirus - Gammaherpesvirus 68 ORF27 gene product contributes to intercellular viral spread

Herpesvirus - Stimulation of latently infected B cells triggers gammaHV68 reactivation

Hodgkin Disease - Clinical course of thoracic cancers traced in Hodgkin disease survivors

Human Papillomavirus - Patient sampling of type-specific HPV compared to clinician-directed sampling

Hyperparathyroidism - Minimally invasive surgery for treatment of hyperparathyroidism described

Hypothermia - Perioperative hypothermia did not enhance risk of cancer dissemination

Imaging - Sale of imaging device to U.K. Christie Hospital to treat skin cancer announced

Imaging - Technology company launches pulmonary artery patency exam tool for CT

Influenza - Phase 3 data for intranasal influenza vaccine trial reported

Kaposi Sarcoma-Associated Herpesvirus - Sexual orientation associated with Kaposi sarcoma-associated herpesvirus subtype

Leukemia - Chronic lymphocytic leukemia family 'Pedigree 14' revisited

Leukemia - Research in leukemia provides new insights

Leukemia - Stem-cell transplantation overcame poor prognosis of unmutated VH gene in CLL

Liver Cancer - Findings advance knowledge in liver cancer research

Lung Cancer - Multimodality therapy suggested for stage III non-small-cell lung cancer

Lymphoma - Efficacy of treatments for MALT lymphoma of the stomach assessed

Lymphoma - New discovery on malignant lymphoma treatment revealed at conference

Lymphoma - Proportion of patients with lymphoma may harbor mutations of perforin gene

Malignant Lymphoma - Data shows Zevalin effective second-line treatment for large B-cell lymphoma

Matrix Metalloproteinase - Areca quid chewing enhanced expression of salivary matrix metalloproteinase-9

Medical Devices - Norwegian cancer center selects radiotherapy technology equipment for upgrade

Medullary Cancer - Findings from long-term follow-up of intramedullary spinal cord tumors discussed

Melanoma - BRAF and NRAS mutations uncommon in melanomas arose in diverse internal organs

Melanoma Vaccine - Mimotope reactivity against melanoma does not predict immunogenicity

Merkel Cell Cancer - Merkel cell carcinoma of the skin with leptomeningeal metastases described

Merkel Cell Carcinoma - Adjuvant radiotherapy improved outcome of Merkel cell carcinoma

Metastatic Disease - Androgen deprivation used to treat minimal metastatic disease

Multiple Myeloma - Biopharmaceutical company publishes results from clinical trials

Neuroepithelial Cancer - Recurrent intractable seizures occurred in children with cortical dysplasia

Neurology - Angiogenic gene therapy diminishes cisplatin-induced peripheral neuropathy

Neurology - Immunoglobulin class switch occurred in primary lymphomas of CNS

Non-Hodgkin Lymphoma - Genasense plus Rituximab reported active in patients with relapsed NHL

Non-Hodgkin Lymphoma - Nuclear medicine provides alternatives to traditional chemotherapy treatment

Non-Hodgkin Lymphoma - Phase II study data demonstrates galiximab may be used with RITUXAN

Non-Hodgkin Lymphoma - Treatment may improve efficacy of rituximab in non-Hodgkin lymphoma

Oncogenesis - Connexin32 relies on angiogenic blockade to stop renal cell carcinoma growth

Oncogenesis - TNF receptor-II gene variations are linked to breast cancer survival

Oncology - Angiogenesis values offer prognostic information about Hodgkin lymphoma

Oncology - Combination therapy beats cancer by focusing on angiogenesis

Oncology - Distant metastases predicts ischemic stroke in cancer patients

Oncology - Lymphangiogenesis signals the spread of head and neck cancer

Oncology - P12 gene therapy attacks head and neck cancer in mouse models

Oncology - Promoters help an Escherichia coli suicide gene kill pancreatic cancer

Oncology - Reports advance knowledge in oncology research

Oncology - Therapy centered on KIT exon 8 mutants may treat core binding factor leukemia

Oral Cleft - Cancer risk in persons with oral cleft examined

Otorhinolaryngology - Oral immunonutrition of ambulatory head and neck cancer patients studied

Ovarian Cancer - CA-125 AUC prognosticated ovarian cancer

Ovarian Cancer - Combination therapy of gemcitabine and carboplatin treated ovarian cancer

Ovarian Cancer - Common death receptor 4 polymorphisms not predisposed to ovarian cancer

Ovarian Cancer - DCS liquid-based system deemed more effective than conventional smears

Ovarian Cancer - FDG PET holds promise for more accurate assessment of response to chemotherapy

Ovarian Cancer - Polymorphism in FANCA promoter region associated with breast and ovarian cancer

Ovarian Cancer - Research in ovarian cancer provides new insights

Ovarian Health - Case control study of glycoprotein status in ovarian carcinoma conducted

Ovarian Health - Stem-like cells contribute to aggressive behavior of epithelial ovarian cancer

Ovarian Tumors - Artificial neural network computer model predicts malignancy

Paclitaxel - Adenocarcinoma of mammary-like glands in the vulva treated by weekly paclitaxel

Paclitaxel - Paclitaxel chemotherapy treated cancer of ovary, peritoneum, and fallopian tube

Pain Medicine - CyberKnife stereotactic radiosurgery treated spinal tumors

Pain Medicine - Survey shows physicians and consumers approve of medicinal marijuana use

Pancreatic Cancer - Defective DNA mismatch repair associated with long-term survival

Pancreatic Cancer - JAK2 activation by G protein-coupled receptor implicated in pancreatic tumors

Pancreatic Cancer - PET compared to CT for diagnosis and staging of pancreatic cancer

Pancreatic Cancer - Pylorus-preserving duodenopancreatectomy compared to classical Whipple resection

Personnel - Beverly Mitchell, MD, joins Stanford University's cancer center program

Personnel - Biopharma company expands diabetes research efforts with key scientists

Personnel - Breast cancer expert joins oncology and hematology clinical practice

Personnel - Cancer institute adds four senior leaders

Personnel - E. Michael Egan named chief executive officer by cancer-focused biotech company

Personnel - ImmunoGen, Inc. Announces Addition of Nicole Onetto, MD, to Board of Directors

Personnel - Patricia M. Neal named 2005 Ethel Fleming Arceneaux Outstanding Nurse-Oncologist

Personnel - Two new members named to board by nonprofit cancer support organization

Pharmaceutical Research - Study examines amount biotechs spending on oncology brand commercialization

Pharmaceutical Research - Study examines state of pharmaceutical industry

Pituitary Gland - Difficulties in differentiating between pituitary abscess and apoplexy discussed

Pituitary Gland - Pituitary carcinoma clinicopathologically reviewed

Pneumocystis Jiroveci Pneumonia - PCP may be a contagious disease in stem cell transplant recipients

Pregnancy - Adenocarcinoma in situ of the cervix in pregnancy described

Prognostics - Prognostic factors and scoring system for skeletal metastasis developed

Prognostics - Prognostic significance of lymphovascular invasion assessed

Prognostics - Thymidylate synthase polymorphisms prognosticated gastric cancer

Prostate Cancer - A/G polymorphism of core 2 branching enzyme gene associated with prostate cancer

Prostate Cancer - Active surveillance with selective delayed intervention managed prostate cancer

Prostate Cancer - Blood and tissue selenium concentrations associated with prostate cancer

Prostate Cancer - Combination chemotherapy with docetaxel, estramustine, and suramin evaluated

Prostate Cancer - Combined radical prostatectomy and bladder augmentation treated prostate cancer

Prostate Cancer - Extraprostatic extension near neurovascular bundles predicted by novel algorithm

Prostate Cancer - Green tea used to treat hormone refractory prostate cancer

Prostate Cancer - MAD-CaP-5 could be explored as a novel prostate cancer antigen

Prostate Cancer - Prostate stem cell antigen is overexpressed in prostate cancer metastases

Prostate Disease - Noninvasive prostate disease treatment approved in Canada

Pseudomyxoma Peritonei - Peritoneal mucinous diseases reviewed

Psoriatic Arthritis - Data show sustained efficacy of infliximab in treating psoriatic arthritis

Psychological Disorders - Brain tumors in children caused cognitive and psychological disorders

Quality Assurance - Cancer stage at diagnosis differs between HMO and fee-for-service Medicare

Radiation Therapy - Model devised for Varian EDW factors at off-center points

Rectal Cancer - Clinical examination after preoperative chemoradiation found unreliable

Rectal Cancer - Clinical significance of enhancer of zeste homolog 2 expression studied

Rectal Cancer - Maximum tolerated dose of gemcitabine calculated

Rectal Cancer - Role of radiotherapy in rectal cancer evaluated

Reproductive Medicine - Conservative surgery preserves fertility in women with borderline ovarian tumors

Reproductive Medicine - New methods may preserve fertility for girls receiving cytotoxic therapy

Reproductive Medicine - Transplantation of sperm stem cells restores fertility after chemotherapy

Spinal Tumor - Osteochondroma of the sacrum evaluated

Stem Cell Research - Agreement signed for worldwide distribution of stem cell identification kit

Stem Cell Transplantation - Early complete donor hematopoietic chimerism indicates risk of extensive GVHD

Stem Cell Transplantation - Findings advance knowledge in stem cell transplantation research

Stem Cell Transplantation - Multiplexed real-time PCR monitors adenovirus DNA load in transplant patients

Stomach Cancer - Clinical practice guidelines for 2004 outlined

Thrombosis - Approaches to management of deep vein thrombosis in cancer discussed

Thyroid Gland - Decreased type I iodothyronine deiodinase expression indicated papillary cancer

Type 2 Diabetes - Biopharma company presented diabetes research at conference

Upper Gastrointestinal Disease - Circulating ghrelin levels vary with disease type

Urology - Pelvic lymph node bladder cancer micrometastases underlies recurrence

Vaginal Cancer - PET scans are better at tumor and cancerous lymph node detection than CT

Women's Health - Inside the Calcium Conundrum

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