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Clinical Oncology Week

Susan Hasty, Publisher

Table of Contents . . . July 25th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Clinical Oncology Week | Other Publications

Allergy Medicine - Anti-inflammatory activity of Korean folk medicine 'Sabaeksan' analyzed

Childhood Cancer - Day care in infancy reduced risk of childhood acute lymphoblastic leukemia

Critical Care - The hidden dangers of hospitals exposed

Lung Cancer - Sensor array analyses of exhaled breath detected lung cancer

Thyroid Cancer - Controversies over the management of thyroid cancer raised

Advocacy - Lung cancer nonprofit program launches newly redesigned Internet site

Ameloblastoma - Heparanase gene and protein expression associated with ameloblastoma

Anal Cancer - Chemoradiotherapy is feasible in anal carcinomas in HIV-positive patients

Anicemycin - Anicemycin inhibited anchorage-independent growth of tumor cells

Apoptosis - Induction of NO and ROS caused apoptosis in lymphoma cells

Ataxia - Overview of patients with ataxia presented

Breast Cancer - Studies add new findings to breast cancer body of knowledge

Bioartificial Liver - Microfabricated grooved substrate is platform for bioartificial liver reactors

Bladder Cancer - Developer reports on sales of tests to diagnose bladder cancer

Blood Banking - Quality issues found in banked umbilical cord blood stem cells for transplant

Bone Cancer Pain - Analgesic effects of loperamide in bone cancer pain in mice analyzed

Brain Cancer - Childhood brain tumors not linked to beauty product-related exposures

Brain Cancer Therapy - Novel computational method improves tumor segmentation

Cancer Vaccines - Reports advance knowledge in cancer vaccines research

Breast Cancer - 1H magnetic resonance spectroscopic imaging technique for breast cancer improved

Breast Cancer - Abnormal serum levels increase risk of breast cancer

Breast Cancer - Arimidex granted new indication enabling wider access

Breast Cancer - Cancer patients with recurrence, metastasis present fewer apoptotic cells

Breast Cancer - Clinical significance of transcription factors Snail, Slug, and Twist evaluated

Breast Cancer - Clinicopathologic factors linked to false-negative sentinel lymph-node biopsy

Leukemia - Researchers publish new studies and findings in the area of leukemia

Breast Cancer - Duke University to evaluate Panzem NCD in breast cancer

Breast Cancer - Phytoestrogens and 17 beta-estradiol inhibited apoptosis in breast cancer cells

Breast Cancer - Postmenopausal hormone replacement therapy and risk of cancer debated

Breast Cancer - Reovirus may be used as a purging modality for breast cancer during ASCT

Breast Cancer - Research add new data to breast cancer body of knowledge

Breast Cancer - U.S. patent for breast cancer detection through biomarkers granted

Business & Finance - Cancer-focused corporation secures $30 million in private equity financing

Business & Finance - Spanish biotech board authorizes raising funds through institutional investors

Business Update - Canadian metabolics-focused company closes sale of Celmed BioSciences investment

Cancer Classification - MicroRNA expression profiles classified human cancers

Cancer Prevention - The farnesyltransferase inhibitor ABT-100 prevents liver cancer

Cancer Prognosis - Prognostics of cancer of unknown primary reviewed

Cancer Risk Factors - Associated nutritional risk of breast and colon cancers disproved

Cancer Risk Factors - Cancer incidence and mortality in patients with type 1 diabetes reported

Cancer Survival - Personality not associated with cancer survival

Cancer Therapy - Antibodies to angiogenic protein staunch murine acute myeloid leukemia

Cancer Therapy - Long-term benefits of Aldara cream for actinic keratosis reported

Cancer Therapy - New data illuminates research in cancer therapy

Cancer Therapy - Positive phase-II data reported on pegylated interferon alfa-2b

Cancer Therapy - Proliferative indices predict survival after chemotherapy for breast cancer

Cancer Therapy - Small molecule inhibitors knock down hypoxia-related tumorigenesis

Cancer Treatment - Study probes perceptions, attitudes of oncologists' drug therapy choices

Cancer Vaccines - Reports add new data to cancer vaccines research

Cardiac Myxoma - Caspase-3-dependent apoptosis in cardiac myxoma not associated with HPV or EBV

Cervical Cancer - Chemotherapy included in primary treatment of cervical carcinoma

Cervical Cancer - Expression and prognostic significance of Fas ligand and bcl-2 evaluated

Cervical Cancer - HPV capsid mutation allows escape from cervical cancer immunity

Cervical Cancer - Researchers describe findings in cervical cancer studies

Cervical Cancer - Scientists develop device to detect cervical cancer

Cervical Cancer - Survey flags doctor-patient communication gap regarding HPV and cervical cancer

Cervical Cancer - Texas to require insurers to cover HPV testing for cervical cancer screening

Chemotherapy - Adjuvant anthracycline-based chemotherapy for early breast cancer evaluated

Chemotherapy - Temozolomide used to treat high-grade gliomas

Childhood Cancer - Cancer related to distance from high voltage power lines in England and Wales

Childhood Cancer - Childhood cancer survival trends in Europe tracked

Clinical Trials - Clinical study of Aurora kinase inhibitor in hematologic cancers initiated

Clinical Trials - Decision making process in oncology needed improving

Collaborations - Collaboration with Cryptome Pharmaceuticals signed to validate cancer lead

Collaborations - Collaborations announced for clinical trials in acute ischemic stroke treatment

Collaborations - Pharmaceutical companies announce collaboration in small molecule therapeutics

Colon Cancer - Antiproliferative action of water extracts from raspberry seeds analyzed

Colonoscopy - Automated measurement of colonic polyps compared with manual technique

Colorectal Cancer - Alterations in tissue inhibitor of TIMP-3 implicated in colorectal tumors

Colorectal Cancer - Benchmarks developed for sigmoidoscopy in early detection of cancer

Colorectal Cancer - Risk and prognosis of curative resection of T1 colorectal carcinoma evaluated

Colorectal Cancer - Ten-year outcomes evaluation of colon and rectum cancers conducted

Complementary & Alternative Medicine - FDA issues information about claims for green tea and certain cancers

Cryopreservation - Cryopreservation protocol developed to store 3-D bioartificial liver device

Cytotoxicity Determination - Cytotoxicity determined without photochemical artifacts

DNA Tumor Viruses - ARF-p53 pathway modified by small DNA tumor viruses

Dental Health - Expertise regarding oral cancer among Brazilian dentists found lacking

Dermatology - Dermatologic surgery discussed

Diabetes - TNF-alpha may be a risk for coronary heart disease among diabetics

Diagnostics - Accuracy of techniques for image-guided stereotactic brain biopsy compared

Diagnostics - Bioinformatic screen for novel adenosine-inosine RNA editing sites developed

Diagnostics - Company receives FDA approval for c-Kit pharmDx

Diagnostics - Diagnostic usefulness of aberrant CD22 expression assessed

Diagnostics - Genetics-focused company contracts with cancer center to develop diagnostic test

Diagnostics - Model correction gives accurate assessments of brain tumor hemodynamics

Diagnostics - New findings in the area of diagnostics described

Diagnostics - Novel approach to detect cancer measures fragments of host response proteins

Drug Development - Beta and gamma-secretase inhibitors abate tumor angiogenesis

Drug Development - Natural human alpha interferon approved for sale in Chile

Eye Cancer - Cavitary changes in retinoblastoma related to better prognosis

Fibromatosis - Calcified fibromatosis detected in neck of 4-year-old girl

Finance - Pharma company signs offer for eight million shares of stock

Gastric Cancer - Gastric cancer management strategies recommended

Gastric Cancer - Gastric cancer may originate from circulating bone marrow-derived stem cells

Gastric Cancer - Postoperative detection of gastric cancer cells related to risk of recurrence

Gastroenterology - Hypoxia-inducible factor-1 pushes gastrointestinal stromal tumor progression

Gastroenterology - Secondary gene mutations make gastrointestinal tumors resist imatinib

Gastrointestinal Stroma Tumor - New research bolsters highly targeted gastro-intestinal cancer treatment

Geriatric Cancer - Treatment practices for elderly cancer patients in Ontario, Canada, analyzed

Gliomas - CED drug delivery technique reviewed

Gynecology - Endometrial cancer patients respond to carboplatin and taxol

Head and Neck Cancer - Dermatofibrosarcoma protuberans of the face managed surgically

Head and Neck Cancer - Genetic profiles classify oral squamous cell carcinomas

Hematologic Disease - Phase I study of 506U78 for refractory hematologic malignancies conducted

Hematology - Recent studies add new data to hematology research

Hepatitis B - Study shows effectiveness of hepatitis B treatment

Hepatocellular Cancer - Utility of hepatocellular carcinoma screening reviewed

Hodgkin Disease - SHIELD program officially launched

Hodgkin Disease - The value of CT and MR imaging in Hodgkin disease weighed

Hodgkin Lymphoma - Current treatment strategies of the German Hodgkin Study Group (GHSG) revealed

Hodgkin Lymphoma - Novel chemotherapies for Hodgkin lymphoma being investigated

Hormonal Therapy - Appropriate use of hormones reduces risk of comorbidities

Human Papillomavirus - Diagnostics company received CE mark for Linear Array HP Genotyping Test

Human Papillomavirus - HPV 63 targets keratinocytes in or around eccrine ducts in plantar skin

Human Papillomavirus - New findings in human papillomavirus described

Imaging - Massachusetts hospital selects upgraded, dedicated breast MRI system

Intracranial Cancer - Choices of surgical approaches for septum pellucidum tumors compared

Intraperitoneal Chemotherapy - Insertion of intraperitoneal port for chemotherapy detailed

Laminin - Role of laminin in tumor progression discussed

Laparoscopy - Indications and benefits of diagnostic laparoscopy discussed

Leukemia - Findings in leukemia provide new insights

Leukemia - Maternal exposure to occupational solvents not linked to childhood leukemia

Liver Cancer - Angiostatic therapy hinders hepatocellular carcinoma progression

Liver Cancer - Liver cancer therapy achieves primary endpoint in phase 2a clinical trials

Liver Cancer - MRI better than FDG PET at detecting liver tumors

Liver Cancer - Prognosis of liver transplantation estimated

Liver Cancer - The hepaCAM gene is silenced in human hepatocellular carcinoma

Liver Transplantation - Alcohol compounds the risk of hepatitis-C-related liver cancer formation

Lung Cancer - Chemotherapy induced expression of cyclooxygenase-2 in lung cancer

Lung Cancer - NAT2 genotype associated with increased risk of lung cancer among never-smokers

Lung Cancer - Node dissection by video-assisted thoracic surgery assessed

Lung Cancer - Positive recommendation in European Union of lung cancer medicine erlotinib

Lymphoma - CD43 coexpressed by benign B cells in the terminal ileum

Lymphoma Diagnostics - Image-guided cutting-edge-needle biopsy diagnosed lymphoma

Medical Malpractice - Medical malpractice concerns lead to more breast biopsies

Melanoma - Different manifestations of malignant melanoma in the breast reported

Melanoma - Differential effects of selenite and selenate delineated

Melanoma - Protein amplification in melanoma is possible drug target

Melanoma - Scientists ID gene driving melanoma cell growth and survival

Melanoma - Skin cancer research receives a massive funding boost

Melanoma - p14ARF interacted with SUMO-conjugating enzyme Ubc9 and promoted sumoylation

Melanoma Vaccine - Melanoma antigen cross-reactivity does not predict immunogenicity

Melanoma Vaccine - Peptides isolated by melanoma antibodies have different immunogenicity

Mental Illness - End-of-life treatment preferences of persons with mental illness discussed

Mergers & Acquisitions - Contract research organization acquires SKM Oncology

Multiple Sclerosis - IND submitted to U.S. FDA for oral treatment of relapsing multiple sclerosis

Nasopharyngeal Carcinoma - Epstein-Barr virus serology aided diagnosis of nasopharyngeal carcinoma

Nasopharynx Cancer - Adnexal carcinoma found in auditory canal 15 years after radiotherapy

Non-Hodgkin Lymphoma - HUMAX-CD20 induces clinical response in NHL at all dose levels, company reports

Non-Hodgkin Lymphoma - Non-Hodgkin lymphomas of the oral cavity characterized by WHO classification

Olfactory Neuroblastoma - Endoscopic-assisted cranionasal resection of olfactory neuroblastoma assessed

Oncogenesis - Interferon is important component of 'cancer immunoediting'

Oncology - Cervical adenocarcinoma in situ can be safely managed during pregnancy

Oncology - Downregulated BRCA2 expression upregulates prostate cancer cell proliferation

Oncology - Effectiveness of combined therapeutic modalities investigated in cervical cancer

Oncology - Interleukin-8 levels rise in advanced prostate cancer

Oncology - Recombinant CXC chemokine ligand 10 boosts the potency of cisplatin

Oncology - Tumor resection prolongs life

Oral Cancer - Cytotoxicity of phenolic acid phenethyl esters on oral cancer cells evaluated

Oral Cancer - Effect of screening on oral cancer mortality in Kerala, India, evaluated

Oral Reconstruction - Clinical outcome of reconstruction of oral cavity reviewed

Orbital Surgery - Procedures for reconstructive and function-preserving orbital surgery discussed

Osteosarcoma - Fluoride in tap water linked to bone cancer

Otorhinolaryngology - F-18-FDG-PET-CT fusion helped plan radiotherapy treatment

Pain Medicine - Constipation a serious problem for cancer patients treated with opioids

Pain Medicine - Disparities between black and white patients with cancer pain identified

Pancreatic Cancer - Inositol hexaphosphate proposed as novel treatment for pancreatic cancer

Patents - U.S. patent allowed for novel cancer drug in clinical development

Pediatric Oncology - Pediatric and adult leukemia cells bear distinctly different properties

Personnel - Biopharmaceutical company announces new president and chief executive officer

Personnel - Breast cancer diagnostics company appoints vice president of sales

Personnel - Cancer therapeutics development company appoints senior vice president

Personnel - Dr. Paul A. Marks named chairman of scientific advisory board

Personnel - Leslie Stiles named honorary chair of Pennsylvania breast cancer group

Personnel - Oncology center company appoints member to board of directors

Personnel - Pharma company hires Sr. VP and general counsel, announces promotion

Pharmaceutical Research - Consultancy releases study on pharma industry

Pheochromocytoma - Genetic testing for pheochromocytoma-associated syndromes recommended

Prostate Cancer - A20 gene expression regulated by TNF, Vitamin D, and androgen in prostate cancer

Prostate Cancer - Age at diagnosis decreased over successive generations in PaC families

Prostate Cancer - Androgen deprivation therapy associated with fracture risk in prostate cancer

Prostate Cancer - Early prostate cancer screening may reduce mortality rate

Prostate Cancer - No serological evidence of association between prostate cancer and HSV2/HSV8

Prostate Cancer - No single PSA cutoff would yield both high sensitivity and high specificity

Prostate Cancer Vaccine - Prostate cancer therapy with inducible caspase and IL-12 described

Proteomics - Protein signatures emerge in hepatocellular carcinoma samples

Public Health - Health indicators helped define public health priorities

Radiotherapy - Radiation-induced apoptosis preceded the delayed apoptosis of CGL1 hybrid cells

Rectal Cancer Therapy - Sacral neuromodulation effective for post-resection incontinence

Renal Transplantation - Cytokine polymorphisms did not influence rejection in renal transplantation

Salivary Glands - Cases of intraoral minor salivary gland neoplasms reviewed

Skin Cancer - Bowen disease treated with Mohs micrographic surgery

Skin Cancer - Mouse model may provide approach to testing the importance of genetic mutations

Squamous Cancer - Polymorphisms of GPX1 gene associated with second primary tumors

Thymic Cancers - Results of multimodality treatments revealed

Thymus Cancer - Chromosomal imbalances occurred in sporadic neuroendocrine tumors of the thymus

Thyoma Therapy - Adjuvant radiation may not be needed after stage III tumor resection

Tobacco Use - Education and employment characteristics predicted smoking status

Trial Parameters - International project launched to harmonize trial parameters in lymphoma

Urology - Genetic markers predict clinical outcomes in bladder cancer patients

Vaccine Development - Pharmaceutical company announces U.S. FDA reviews of investigational vaccines

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