Genetics & Genomics
Antithetical effect of tumor necrosis factor-alpha gene polymorphism on CWP
Published in Clinical Oncology Week, August 29th, 2005
According to a study from Japan, "Inter-individual variation in the severity of pneumoconiosis has been described, even with the same environmental exposure. We hypothesized that TNF-alpha promoter polymorphisms associate with lung responses to environmental exposure in CWP patients."
"We examined polymorphisms at -238, -308, and -376 in 124 patients with CWP who had similar dust exposure history and in 122 non-exposed controls. CWP patients were divided into two groups: (1) nodular CWP (n=84): (2) progressive...
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