Published in Clinical Oncology Week, September 12th, 2005
"Clinical trials have been initiated with Apo2L/TRAIL (Genentech) and agonistic mAbs to TRAIL receptors, -R1 and -R2 (Human Genome Sciences). The apoptosis-inducing ability of these mAbs and different TRAIL preparations, in the presence or absence of histone deacetylase inhibitors (HDACi), varied markedly against primary CLL cells and various tumor cell lines, demonstrating an unanticipated preferential apoptotic signaling via either TRAIL-R1...
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