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Clinical Oncology Week

Susan Hasty, Publisher

Table of Contents . . . September 19th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Clinical Oncology Week | Other Publications

Gastric Cancer - Continuous 5-fluorouracil infusion followed by weekly paclitaxel

Leukemia - Protocol for the treatment of newly diagnosed APL children delineated

Shark Cartilage - Use of shark cartilage evaluated in patients with advanced cancer

Vinorelbine - Vinorelbine monotherapy used in advanced or recurrent breast cancer

Adjuvant Cancer Therapy - Guided imagery as adjuvant cancer therapy reviewed

Alopecia - Hair loss accompanied chemotherapy

Analgesia - Postoperative pain after supratentorial craniotomy reduced by scalp infiltration

Analgesia - Pros and cons of opioid rotation in cancer patients discussed

Anemia - Impact of weekly dosing of epoetin alfa on anemic cancer patients examined

Anemia - Pretreatment anemia associated with poorer survival in gastric cancer patients

Breast Cancer - Findings in breast cancer provide new insights

Angiology - Risk of catheter-related bloodstream infection assessed

Antioxidants - Antioxidant micronutrients have beneficial effects

Antioxidants - Effects of Turkish pollen and propolis extracts on respiratory burst studied

Apoptosis - Apoptosis-based therapies for hematologic malignancies discussed

Apoptosis - Mast cell apoptosis analyzed, tetracycline induction revealed

Apoptosis - Researchers describe findings in apoptosis studies

Breast Cancer - Reports advance knowledge in breast cancer research

Apoptosis - Skin injury-related genes in human keratinocytes identified

Apoptosis - TrkA induced apoptosis of neuroblastoma cells via p53-dependent mechanism

Awards - Australian offers $2.98 million commercialization grant for cancer drug

Awards - Walter C. Willett, MD, doctor of public health, wins nutrition research award

Biliary Obstruction - Endoscopic US-guided drainage effective in benign and malignant disease

Bladder Cancer - Occupational cancer risks in British Columbia estimated

Breast Cancer - Research add new data to breast cancer body of knowledge

Bladder Cancer - Patient preferences for improved chemotoxicity reviewed

Bladder Cancer - SIAC with mitomycin C used to treat gallbladder cancer

Bone Cancer - Prostate cancer uses Wnt signaling proteins to promote growth of bone tumors

Breast Cancer - Age a factor in breast cancer risk with previous oral contraceptive use

Breast Cancer - Approaches to managing bone metastases from breast cancer shared

Breast Cancer - Attitudes about perception of risk shift after breast cancer counseling

Breast Cancer - Researchers detail new studies and findings in the area of breast cancer

Breast Cancer - Attitudes of couples on pregnancy after diagnosis of breast cancer studied

Breast Cancer - Behavior patterns analyzed in post-diagnosis breast cancer patients

Breast Cancer - Beliefs and adaptation strategies of Hong Kong breast cancer patients discussed

Breast Cancer - Benefit of support groups for women diagnosed with breast cancer discussed

Breast Cancer - Breast cancer protein biomarkers discovered in studies of blood serum

Breast Cancer - Cancer risk examined across common differences in breast cancer gene

Breast Cancer - Researchers publish new studies and findings in the area of breast cancer

Breast Cancer - Communicating information regarding adjuvant chemotherapy reviewed

Breast Cancer - Dietary flaxseed potentially alters tumor markers in breast cancer

Breast Cancer - Dioxin levels examined as breast cancer risk factor

Breast Cancer - Effective communication enhances patient satisfaction and decision-making

Breast Cancer - Effects of radiation therapy studied on esophageal transit in breast cancer

Breast Cancer - Ethnic differences in breast cancer incidence and survival compared

Breast Cancer - Studies advance knowledge in breast cancer research

Breast Cancer - Factors identified that influence women's decision making for cancer treatment

Breast Cancer - Findings advance knowledge in breast cancer research

Breast Cancer - Folate intake examined for role in risk reduction in certain breast cancers

Breast Cancer - FoxA1 regulates estrogen receptor binding in tumor cells

Breast Cancer - Fulvestrant compared to anastrozole for treatment of advanced breast cancer

Diagnostics - New findings in the area of diagnostics detailed

Breast Cancer - Global trends analyzed for breast cancer incidence and mortality

Breast Cancer - Incidence rate of tumor recurrence after breast-conserving therapy studied

Breast Cancer - Information and support needs of callers to Cancer Helpline addressed

Breast Cancer - Intraoperative frozen-section analysis used to measure lumpectomy-bed margins

Breast Cancer - Japanese agency OKs added use for leuprorelin acetate injection in breast cancer

Breast Cancer - Needs of women with metastatic breast cancer identified

Hematology - Recent findings in hematology described

Breast Cancer - Quality of breast cancer care assessed

Breast Cancer - Quality of life issues compared for breast cancer survivors

Breast Cancer - Quality of life issues following breast cancer treatment analyzed

Vector Development - New findings in vector development described

Breast Cancer - Vitamin D sensitized breast cancer cells to H2 O2

Breast Cancer - Vitamin D studied as agent for reduction of breast cancer risk

Breast Cancer Prevention - Optimal dosing for Indole-3-carbinol investigated

Breast Cancer Risk Factors - Breast cancer risk, alcohol intake in Japanese women studied

Breast Cancer Risk Factors - Estrogen metabolism-related genes and breast cancer risk studied

Breast Carcinoma - Undifferentiated-type breast carcinomas identified by KIT/EGFR overexpressions

Cancer Diagnosis - Cancer patients cared for in non-specialist wards

Cancer Diagnosis - Do gender differences influence reaction to cancer diagnosis?

Cancer Education - Information for cancer patients reviewed

Cancer Education - Information needs and sources of information among cancer patients discussed

Cancer Incidence - Cancer incidence among Danish brewery workers estimated

Cancer Inhibitors - Histone deacetylase inhibitors affected Ewing family tumors

Cancer Research - Biopharma company presented updated data on Combretastatin A4 Prodrug

Cancer Research - Preclinical data supporting development of Oxi4503 presented

Cancer Research - Study demonstrates potential of focusing on individual protein compositions

Cancer Research - U.S. FDA approves special protocol assessment for phase III PRECISE trial

Cancer Risk Factors - Body mass index and serum hormone levels examined as predictors for cancer risk

Cancer Risk Factors - Human risk assessment of As, Cd, Cu and Zn in abandoned metal mine site

Cancer Risk Factors - Risk of cancer increased among siblings of long-term childhood cancer survivors

Cancer Screening - Season, sun, and sex related to incidence of cervical cancer

Cancer Screening - Women's misconceptions about cancer screening affected informed decision-making

Cancer Surgery - Post-resection mucosal margin shrinkage observed in oral cancer

Cancer Therapy - Camptothecin derivatives synthesized

Cancer Therapy - Chicken-produced better than conventionally produced antibodies

Cancer Therapy - Cisplatin used to treat large cell neuroendocrine carcinoma of the lung

Cancer Therapy - Highly efficient intrabody mediates VEGF signal inhibition

Cancer Therapy - Magnetic nanoparticles based on metallic iron are potential new cancer treatment

Cancer Therapy - Modified metronomic combination therapy has a sustained effect against cancer

Cancer Therapy - New findings in the area of cancer therapy detailed

Cancer Therapy - Pluripotent bradykinin antagonists fight cancer using a multiprong approach

Cancer Therapy - Researchers identify new anticancer, anti-infection response control mechanism

Cancer Therapy - Stealth particles target tumors

Cancer Therapy - Toxicity predicts effective chemotherapy dose

Cancer Therapy - Tumor stroma is an important target during T-cell-mediated tumor rejection

Cancer Treatments - Analysis of therapy-resistant tumors reveals SPARC as a cancer therapy target

Cancer Treatments - Gender differences in treatment decision-making compared

Cancer Treatments - PA appears to have antitumor activity, increases the antitumor activity of DOX

Cancer Vaccines - Researchers report details of new studies and findings in the area of cancer vaccines

Carcinogenesis - Multi-residue method determined thyreostats in urine samples

Cardiovascular Disease - CV risk is lower in rheumatoid arthritis patients treated with TNF blockers

Caregiving - Discrepancy found in the preferences of place of death

Caregiving - Support requirements for caregivers of patients with palliative cancer listed

Cervical Cancer - G-308A TNF-alpha polymorphism associated with increased risk of cervical cancer

Chemotherapy - Mylotarg administered after start of chemotherapy produced high remission rate

Chemotherapy Side Effects - Incidence of chemotherapy-induced nausea and vomiting in Taiwan analyzed

Chondrosarcoma - Long-term oncologic outcome of chondrosarcoma of the scapula described

Chronic Myelogenous Leukemia - Protein kinase inhibitors put under high throughput screening

Cisplatin - Antipyrine test predicted docetaxel and cisplatin chemotherapy pharmacodynamics

Cisplatin - Efficacy and safety of intravenous topotecan combinatory chemotherapy tested

Clinical Trials - Phase 2 trial of combination drug in advanced pancreatic cancer initiated

Clinical Trials - Study shows docetaxel injection with paclitaxel improves breast cancer survival

Collaborations - Digital mammography results available on Sectra multimodality

Collaborations - Target selection made from research alliance in cancer

Collaborations - University of Kentucky, biomarker research firm partner to fight ovarian cancer

Colon Cancer - High oxygen radical production found in patients with sporadic colorectal cancer

Colon Cancer - Thalidomide arrests colorectal cancer metastasis without affecting angiogenesis

Colorectal Cancer - Chemotherapy induced diarrhea in patients with colorectal cancer

Colorectal Cancer - Dietary benzo[a]pyrene intake related to risk of colorectal adenoma

Colorectal Cancer - Microsatellite-unstable colorectal cancer treated with 5-fluorouracil

Colorectal Cancer - Pharma company doses colon cancer patients in Davanat phase II trial

Colorectal Cancer - Researchers' work adds to colorectal cancer body of knowledge

Colorectal Cancer - US-guided endoscopic mucosal resection effective for submucosal tumors

Complementary & Alternative Medicine - A sugar ester and an iridoid glycoside isolated from S. ningpoensis

Complementary & Alternative Medicine - Complementary and alternative medicine used by Brazilian oncologists

Constipation - Positive results from methylnaltrexone phase 3 clinical trial reported

Coping Strategies - Communication strategies for pediatric cancer healthcare workers reviewed

Cystectomy - Clinical outcomes of radical cystectomy compared between young and old patients

Cytoreductive Surgery - Cytoreductive surgery improves prognosis in ovarian metastasis

Depression - Complementary medicine used by some breast cancer patients to combat depression

Depression - Physician-patient communication among southern European oncologists examined

Diagnostics - Diagnosis of brain metastasis of unknown primary discussed

Diagnostics - Hybrid capture for HPV-related cervical infection in HIV/AIDS sensitive/specific

Diagnostics - New findings in the area of diagnostics described

Diet & Nutrition - Article provides overview of database of research on dietary supplements

Diet & Nutrition - Recent findings in diet & nutrition provide new insights

Dlk1 Overexpression - Dlk1 may be overexpressed in myelodysplastic syndrome and acute myeloid leukemia

Drug Delivery - Granisetron delivery by iontophoretic patches characterized

Drug Delivery - Intratumoral injection of BCNU in ethanol resulted in enhanced delivery to tumor

Drug Development - Anticancer compound cleared to advance into human clinical trials

Drug Development - Antisoma granted U.S. orphan drug status for AS1411 in renal cancer

Drug Development - Canadian authorities approve phase III trial of cancer drug

Drug Development - Doxazosin targets prostate cancer angiogenesis

Drug Development - Marketing applications to be submitted for Xyotax in U.S, Europe

Drug Development - Novel class of drug candidates identified from small molecule anticancer program

Drug Development - Orphan drug designations granted for AP23573

Drug Development - Partnership signed for therapy targeting development of tumor vasculature

Endometrial Cancer - Resistance of endometrial cancer to radiation therapy examined

Endometrial Cancer - Surgical treatments of endometrial cancer compared

Environmental Health - Arsenic contamination in water, soil, sediment and rice of central India

Epidemiology - Basosquamous carcinoma treated with Mohs micrographic surgery

Esophageal Cancer - Palmoplantar keratoderma associated with ESCC in Van Region of Turkey

Esophageal Cancer - Second malignancy caused death in thoracic squamous cell esophageal cancer

Etoposide - Irinotecan, etoposide used in previously untreated, extensive SCLC

Finance - Biopharma company reports revenue of $71.3 million

Finance - Cancer-focused biopharmaceutical company reports board ratification of loans

Finance - Pharma company awarded small business grants totaling over $1.2 million

Finance - Psoriasis, breast cancer technology developer reports second quarter progress

Gastrectomy - Experience recommended for performing D2 gastrectomy

Gastric Cancer - Etiology of gastric cancer discussed

Gastric Cancer - Findings describe new data in gastric cancer research

Gastric Cancer - Usefulness and limitation of multiple endoscopic biopsy sampling assessed

Gastric Cancer - Weekly oxaliplatin plus infusional fluorouracil and folinic acid regimen tested

Gastroenterology - New findings in gastroenterology described

Gastroesophageal Reflux Disease - Need to test for H. pylori before treating GERD proposed

Germ Cell Cancer - Gene expression-based classifier developed

Glossectomy - Reconstruction of total and near-total glossectomy defects reviewed

Glossitis -  H. pylori associated with glossitis and halitosis

Gynecology - Recent findings in gynecology provide new insights

Head & Neck Cancer - Mental status and quality of life in patients with head and neck cancer assessed

Head & Neck Cancer - Study could help tailor treatment for head and neck cancer patients

Hematology - New findings in hematology described

Hepatocellular Cancer - Adenoid cystic carcinoma of maxillary sinus analyzed

Hepatocellular Cancer - Genotype-phenotype relationships determined HCC tumors

Hepatocellular Cancer - MRI findings of hepatocellular adenomas revealed

Hepatocellular Cancer - Nonsurgical therapies of hepatocellular carcinoma evaluated

Hepatocellular Cancer - Surveillance and diagnosis of hepatocellular carcinoma discussed

Hepatocellular Cancer - Young children with aflatoxin exposure lack a mutation linked to liver cancer

Hepatocellular Carcinoma - Cancer risk factors outweigh ethnicity for liver cancer survival

Human Papillomavirus Vaccines - Recent findings illuminate research in human papillomavirus vaccines

Hypnotherapy - Feasibility of hypnotherapy for treating symptoms in cancer patients reviewed

Imaging Modality - Pitfalls of interpreting whole-body PET/CT images highlighted

Inhibitors - Flavonoid glycosides inhibited oral cancer cell proliferation

Intracranial Cancer - Spinal irradiation was not beneficial as primary treatment

Kidney Cancer - Multidetector computed tomography compared to magnetic resonance imaging

Lentigo Maligna - Perimeter technique proposed as alternative to Mohs micrographic surgery

Leucovorin - Adjuvant chemotherapies for curative resected colon carcinoma compared

Leucovorin - Intravenous 5-FU compared to oral UFT both modulated by leucovorin

Leukemia - Ethnic difference in daycare attendance and early infections related to ALL risk

Leukemia - Health watch exposure estimates underestimated benzene exposure

Leukemia - Wnt16 inhibition induced apoptosis in ALL cells

Liposarcoma - Liposarcoma of the tongue clinically underdiagnosed

Liver Cancer - Deaths related to hepatocellular carcinoma are on the rise in Japan

Liver Cancer - Fatigue patterns studied in liver cancer patients receiving chemoembolization

Liver Metastasis - Contrast-enhanced ultrasonographic imaging diagnosed liver metastatic lesions

Liver Resection - Liver resection performed for metastatic gastrointestinal stromal tumors

Lung Cancer - Adrenalectomy performed for solitary adrenal metastases from NSCLC

Lung Cancer - Asian ethnicity and adenocarcinoma histology predicted response to gefitinib

Lung Cancer - Candidate tumor suppressor gene TRIT1 in human lung cancer identified

Lung Cancer - Clinical trial of investigational treatment for bronchioloalvealor cancer begun

Lung Cancer - Fluorescence in situ hybridization compared with conventional cytology

Lung Cancer - High prevalence of occult endobronchial malignancy found in high-risk patients

Lung Cancer - New findings in the area of lung cancer detailed

Lung Cancer - Non-small cell lung cancer trial with nimotuzumab cleared by Health Canada

Lung Cancer - Patients' perspectives on refusing diagnosis or treatment revealed

Lung Cancer - Ramifications of severe organ dysfunction in newly diagnosed SCLC patients

Lung Cancer - Reduction in BCL-2 levels helped induce apoptosis in lung cancer cells

Lung Cancer - Researchers find drug that blocks spread of lung cancer in mice

Lung Cancer - TBNA used to diagnose endobronchial malignant lesions

Lung Cancer - Value of palliative radiotherapy in elderly people with lung cancer assessed

Lymphoma - Deoxycoformycin used to treat splenic marginal zone lymphoma

Lymphoma - Relation between benzene exposure and non-Hodgkin lymphoma studied

Malaria - Recent findings in malaria provide new insights

Managed Healthcare - Healthcare team-patient relationship studied

Marketing - Report says marketers should match oncology product to appropriate activities

Medical Devices - Developer of colonscope diagnostic system raises $10 million from syndicate

Medical Devices - HIFU Sonablate 500 receives TGA market approval in Australia

Melanoma - Etiologic factors predicted nevus-associated cutaneous malignant melanoma

Melanoma - Paper reports late preclinical step validating novel melanoma vaccine

Melanoma - Potential etiology for skin cancer recurrence described

Melanoma - Recent studies add new data to melanoma research

Melanoma - Sunscreens and melanoma discussed

Meningioma - Merlin tumor suppressor inhibited Ral guanine nucleotide dissociation stimulator

Meningitis - Skull base defects reconstructed

Mental Health - Patients with hematological malignancies showed a restricted body image

Methotrexate - Etanercept treatments for refractory ocular sarcoidosis evaluated

Multiple Myeloma - Researchers find celecoxib is tough tumor fighter

Myelodysplastic Syndromes - Proper cytogenetic examination of myelodysplastic syndromes detailed

Myeloma - 2-Methoxyestradiol at low dose induced differentiation of myeloma cells

Myeloma - Zoledronic acid down-regulated adhesion molecules of bone marrow stromal cells

Neurogenesis - Shc3 affects high-grade astrocytoma survival

Neuropathic Pain - Long-term intrathecal S(+)-ketamine treated cancer-related neuropathic pain

Occupational Health - New research in the area of occupational health detailed

Oncology - Arsenic compounds halt VEGF-induced endothelial cell proliferation

Oncology - Enzastaurin lends a multifaceted tactic for cancer inhibition

Oncology - Microvessel counts predict melanoma recurrence after cancer therapy

Oncology - Recent studies add new data to oncology research

Oncology - Recombinant human erythropoietin suppresses intratumoral blood vessels

Oral Cancer - Dye imaging identifies oral lesions likely to become cancer

Oral Cancer Surgery - Effects of dental implants on bone graft outcome clarified

Ovarian Cancer - Does breastfeeding reduce the risk of ovarian cancer?

Ovarian Cancer - Effectiveness of synthetic retinol 4-HPR evaluated for chemoprevention

Ovarian Cancer - Evaluating benefit received from knowledge of treatment strategies

Ovarian Cancer - Researchers' work adds to ovarian cancer body of knowledge

Ovarian Cancer - Topotecan in pretreated patients with recurrent ovarian carcinoma evaluated

Ovarian Cancer Risk Factors - Body weight and body mass index related to ovarian cancer risk

Ovarian Tumors - Outcomes of fertility-sparing surgery for ovarian tumors reported

Palliative Care - Challenges of caring for children with uncurable cancer addressed

Palliative Care - Domiciliary occupational therapy service in palliative cancer care evaluated

Pancreatic Cancer - Therapies that modulate c-Src may control cancer of the pancreas

Patient Care - Directives for truth disclosure to patients outlined

Patient Education - Telephone helpline compared to website for cancer information

Patient Satisfaction - Patient satisfaction and quality of life in cancer outpatients determined

Personnel - Biopharma compound developer names new board member

Personnel - Maker of cancer therapy systems announces management promotions

Pneumonia - Community-acquired bacteremic pneumococcal pneumonia in adults analyzed

Product Licensing - Pharmaceutical company enters licensing agreement with Medarex

Prognostics - Reclassification of renal cell carcinoma patients improved prognostic accuracy

Prostate Cancer - Balsalazide may prevent symptoms of radiation-induced proctosigmoiditis

Prostate Cancer - Partnership status influenced quality of life in low-income, uninsured men

Prostate Cancer - Robot-assisted prostate surgery has possible benefits, high cost

Prostate Cancer - Serum PSA level, prostate volume studied in Arab men

Prostate Cancer - Vitamin D, NSAIDS provide double whammy against prostate cancer

Proteomics - Protein-protein interactions regarding cancer reviewed

Pulmonary Medicine - Carbonyl reductase declines with non-small cell lung cancer progression

Rectal Cancer - Response following long-course neoadjuvant chemoradiotherapy analyzed

Rectal Cancer - Treatment outcome since introduction of total mesorectal excision revealed

Rectal Cancer - U.S. FDA grants clearance of pharmacogenetic test for in vitro diagnostic use

Self-Efficacy Measures - Communication and attitudinal self-efficacy scale for cancer developed

Skin Cancer - Comparative genomic hybridization in extramammary Paget disease discussed

Solid Tumors - Epoetin alfa 40000 U once weekly and intravenous iron supply treated solid tumor

Spousal Support - Prostate cancer survival viewed through perspective of elderly Asian wives

Squamous Cell Carcinoma - Health related quality of life evaluated after mandibular resection

Stem Cell Transplantation - Donor CD31 codon 125 genotype correlates with acute GVHD incidence in HSCT

Stem Cell Transplantation - Donor cell allodepletion may reduce severe acute GVHD rate in older patients

Stem Cell Transplantation - KIR genotype protects against leukemic relapse after related HLA-identical HSCT

Stem Cell Transplantation - Leaving central vein catheters in place does not increase SCT-related morbidity

Stomach Cancer - Correlation between tobacco use and stomach cancer in Mizoram, India, analyzed

T-cell lymphoma - Agreement forged to develop and commercialize Genmab's HuMax-CD4

Thioredoxin - Thioredoxin studied in human cells

Thrombosis - Catheter tip position implicated as risk factor for thrombosis

Thymic Tumors - Magnetic resonance imaging evaluated cardiovascular invasion of thoracic mass

Tooth Loss - Tooth loss increased risk of death from upper GI cancer, HD, and stroke

Transplant Medicine - Incidence of OPLC among patients estimated after liver transplantation

Transplant Medicine - Some children face bone marrow transplant risk from dental problems

Tumor Inhibition - EGF-receptor inhibition prevented tumor cell dissemination

Uterine Cancer - Analyzing differences between two types of uterine cancers

Uterine Cancer Treatment - Topotecan evaluated for treatment of uterine carcinosarcoma

Vector Development - New findings in the area of vector development described

Vinorelbine - Vinorelbine combined with gemcitabine in previously treated SCLC patients

Vinorelbine - Vinorelbine-based chemotherapy regimens evaluated in NSCLC patients

Vulvar Cancer - Outcomes of vulvar cancer after negative inguinal lymphadenectomy reported

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