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Acute Myeloid Leukemia

Phase II study to evaluate Xanafide in combination with ara-C for secondary AML

Published in Clinical Oncology Week, November 21st, 2005

Xanthus Life Sciences announced the commencement of a phase II study of Xanafide (amonafide malate) in combination with cytosine arabinoside (ara-C) for the treatment of patients with secondary acute myeloid leukemia (AML).

The phase II study will be conducted at multiple centers in North America and is expected to enroll up to 60 patients with secondary AML, patients with antecedent myelodysplastic syndrome or prior exposure to leukemogenic therapy. Patients will receive a daily dose of Xanafide for 5 days in combination with a standard dose of ara-C as a continuous infusion for 7 days. The primary endpoint of the study is the rate of complete remission, and secondary...

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