Published in Clinical Oncology Week, November 21st, 2005
According to recent research from England, "Many tumor cells are resistant to TNF-alpha-induced apoptosis. Adenovirus early region 1A (AdE1A) sensitizes the otherwise resistant cells to TNF alpha AdE1A also stabilizes the p53 protein."
"The present study demonstrates a correlation between AdE1A-induced sensitization and stabilization of p53 in TNF alpha-induced apoptosis since the N-terminal and CR2 regions, the binding sites for CBP/p300, Rb and 26S proteasome regulatory components, are required for both these actions of AdE1A," explained X....
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