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Cancer Therapy

L-asparaginase may indicate chemotherapy dose changes for obese children with ALL

Published in Clinical Oncology Week, February 6th, 2006

L-asparaginase may be a marker of chemotherapy dose modification in obese children with acute lymphoblastic leukemia.

"The objective of the current study was to compare chemotherapy dose modifications in obese (a body mass index [BMI] >95%) and nonobese (a BMI: 95%) pediatric patients with acute lymphoblastic leukemia (ALL). The study cohort was comprised of 199 pediatric patients diagnosed with ALL who were treated at 1 of 2 South Texas pediatric oncology centers between 1990-2000," scientists in the United States report.

J. Baillargeon and colleagues at the University of Texas explained, "The relative chemotherapy dose modification during the...

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