Adverse Drug Reaction
CYP17 polymorphism may influence tamoxifen-induced hepatic steatosis
Published in Clinical Oncology Week, February 13th, 2006
"Hepatic steatosis is a frequent complication, which sometimes develops nonalcoholic steatohepatitis (NASH), in breast cancer patients treated with tamoxifen, a potent antagonist of estrogen."
"Recently we reported the impairment of fatty acid beta-oxidation and the enhancing fatty infiltration to hepatocytes in aromatase deficiency (ArKO) mice as the estrogen deficiency models. This experimental observation let us speculate a strong link between estrogen and hepatic steatosis," wrote T. Ohnishi and colleagues, Kochi...
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