Published in Clinical Oncology Week, March 27th, 2006
Such cytolytic immunological synapses represent key subcellular structures for specific T cell function and activation, which are normally induced by the interaction of a specific T cell receptor (TCR) on T cells with a corresponding peptide/MHC class I complex on target cells. Intriguingly, BiTE molecules are capable of triggering formation of cytolytic synapses independent of TCR specificity and the expression of MHC class I molecules on target...
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