Published in Clinical Oncology Week, April 3rd, 2006
"RNA interference has become a powerful tool for specific inhibition of gene expression in mammalian cells. Expression constructs allow for the long-term delivery of short interfering RNAs, usually through the expression of Pol III-transcribed hairpins," wrote S.L. Gasior and colleagues, Tulane University.
They continued, "In some instances, these expression systems have been shown to have side effects, including induction of the interferon response and cytotoxicity. Here we...
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