Hepatocellular Carcinoma
HCC tumorigenicity is reduced by knock-down of hepatitis B virus X protein
Published in Clinical Oncology Week, April 10th, 2006
"HBV infection is a major cause of HCC in Southeast Asia and Hong Kong. Among the four proteins that are encoded by the HBV genome, HBV X (HBx) is the most potentially oncogenic factor.
"It is known that HBx plays an important role in hepatocarcinogenesis, but the exact functions and molecular mechanisms of HBx in HCC are not well understood. In this study, we constructed expression vectors for small hairpin RNAs (shRNA) against HBx and investigated their regulatory effects in...
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