Colorectal Cancer
Reports from Netherlands, Germany and People's Republic of China advance knowledge in colorectal cancer research
Published in Clinical Oncology Week, May 1st, 2006
Study 1: The role of mismatch repair gene PMS2 in hereditary nonpolyposis colorectal carcinoma (HNPCC) was clarified.
"The role of the mismatch repair gene PMS2 in HNPCC is not fully clarified. To date, only 7 different heterozygous truncating PMS2 mutations have been reported in HNPCC-suspected families," researchers in the Netherlands reported.
"Our aim was to further assess the role of PMS2 in HNPCC," explained Y.M.C. Hendriks and colleagues, Leiden University. "We performed Southern blot analysis in 112 patients...
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