Published in Clinical Oncology Week, June 26th, 2006
Study 1: Leukemia apoptosis did not always increase alongside granulocytic maturation.
According to recent research from Italy, "In this issue of the Journal, Soucck et al. challenge the assumption that increased functional granulocytic maturation of HL-60, an ATRA-responsive acute myeloid leukemia cell line devoid of the APL-specific PML-RAR alpha fusion protein, results in more rapid or more sustained cell death. In this model cell line, the authors demonstrate that TGF beta 1, a well-known haemopoietic growth factor, enhances retinoid-dependent cyto-differentiation and...
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