Lung Cancer
Lung cancer patient response to irinotecan and cisplatin predicted by UGT1A polymorphisms
Published in Clinical Oncology Week, July 24th, 2006
Researchers in South Korea conducted a study "to determine whether uridine diphosphate-glucuronosyltransferase 1A1, UGT1A7, and UGT1A9 polymorphisms affect the pharmacokinetics (PK) of irinotecan and treatment outcome of Korean patients with advanced NSCLC. Eighty-one patients with advanced NSCLC were treated with irinotecan (80 mg/m2) on day 1 and 8 and cisplatin (60 mg/m2) on day 1 intravenously of each 3-week cycle."
"Genomic DNA was extracted from peripheral blood and genotyped using direct...
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