Melanoma

Melanoma risk increased with loss-of-function mutations in the melanocortin-1 receptor gene

Published in Clinical Oncology Week, July 31st, 2006

An increased risk of melanoma was associated with loss-of-function mutations in the melanocortin-1 receptor gene.

According to a study from the United States, "Melanoma is the most devastating form of skin cancer. The steady increase in the incidence of melanoma, its resistance to chemotherapy, together with its high potential to metastasize, have emphasized the importance of its prevention."

"It is becoming clear that solar ultraviolet radiation is a main culprit in the etiology of melanoma, the same as in basal and squamous cell carcinomas. It is commonly accepted that skin pigmentation and melanin content are principal determinants of the...

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Source: Clinical Oncology Week (2006-07-31)

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