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Colorectal Cancer

Colorectal cancer etiology linked to vitamin D and sunshine exposure

Published in Clinical Oncology Week, July 31st, 2006

The link between colorectal cancer etiology and vitamin D and sunshine exposure could be modulated by the androgen receptor (AR) gene.

"The transcriptional activity of the vitamin D receptor (VDR) gene is regulated, at least in part, by the AR gene. We evaluate how the number of polyglutamine (CAG) repeats of the AR gene influence colorectal cancer in conjunction with vitamin D, sunshine exposure and VDR," scientists in the United States reported.

"Studies of colon (1,580 cases and 1,968 controls) and rectal (797 cases and 1,016 controls) cancer were used," explained M.L. Slattery and colleagues, University of Utah. "Vitamin D intake and average...

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