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Colon Cancer

Roche says phase III trial in metastatic colorectal cancer meets primary endpoints

Published in Clinical Oncology Week, August 28th, 2006

Roche announced that a large, international phase III study (NO16966) enrolling 2035 previously untreated metastatic colorectal cancer patients met both primary endpoints.

Results of the study showed the following:

1) The chemotherapy combination Xeloda plus oxaliplatin, called Xelox, is as effective in terms of progression-free survival - a measure of the time patients live without their disease progressing - as infused 5-fluorouracil/leucovorin plus oxaliplatin, called Folfox;

2) The addition of Avastin to chemotherapy (Folfox and Xelox) significantly improved progression-free survival compared to chemotherapy alone.

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