Retinoblastoma Cell Biology
Recent studies from Michigan State University add new data to retinoblastoma cell biology
Published in Clinical Oncology Week, May 7th, 2007
New research, "Retinoblastoma protein regulation by the COP9 signalosome," is the subject of a report. According to recent research from the United States, "Similar to their human counterparts, the Drosophila Rbf1 and Rbf2 Retinoblastoma family members control cell cycle and developmentally regulated gene expression. Increasing evidence suggests that Rbf proteins rely on multiprotein complexes to control target gene transcription."
"We show here that the developmentally regulated COP9 signalosome (CSN) physically interacts with Rbf2 during embryogenesis. Furthermore, the CSN4 subunit of the COP9 signalosome co-occupies Rbf target gene promoters with Rbf1 and Rbf2,...
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