Cancer

Linking DNA and histone methylation

Published in Clinical Oncology Week, May 14th, 2007

Dr. Michael Carey (UCLA's Jonsson Comprehensive Cancer Center) and colleagues lend new insight into the mechanism of epigenetic silencing of euchromatic genes.

Dr. Carey emphasizes that "The study provides a new direction to understand how histone and DNA methylation, two phenomena that play a significant role in stem cell differentiation and cancer, can communicate with each other to turn genes off. "

Although both histone and DNA methylation have long been recognized as hallmarks of euchromatic gene silencing, how these two processes cooperate to induce silencing has remained unresolved. In their upcoming paper, Dr. Carey and colleagues detail that...

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Source: Clinical Oncology Week (2007-05-14)

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