Osteosarcoma

Research from Seoul National University, Department of Orthopaedic Surgery reveals new findings on osteosarcoma

Published in Clinical Oncology Week, May 21st, 2007

Investigators publish new data in the report "RECK expression in osteosarcoma: correlation with matrix metalloproteinases activation and tumor invasiveness." According to recent research from Seoul, Korea, "Osteosarcoma is a malignant tumor of bone characterized by its high metastatic potential. For the development of metastasis, activation of matrix metalloproteinases (MMPs) is required."

"A novel MMPs inhibitor, reversion inducing cysteine rich protein with Kazal motifs (RECK), is known to down-regulate MMPs and suppress the invasive and metastatic potential in many tumor-derived cell lines and some types of tumors. The expression of RECK and its role in tumor...

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Source: Clinical Oncology Week (2007-05-21)

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