Cancer Gene Therapy

Scientists at Ohio State University, Comprehensive Cancer Center report research in cancer gene therapy

Published in Clinical Oncology Week, July 23rd, 2007

A new study, "FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene," is now available. "The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males," investigators in the United States report.

"Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high rate. The majority of the cancers were mammary carcinomas in which the wild-type Foxp3 allele was inactivated and HER-2/ErbB2 was overexpressed. Foxp3 bound and repressed the HER-2/ErbB2 promoter....

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Source: Clinical Oncology Week (2007-07-23)

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