Cancer
Reports from Soka University, Department of Bioinformatics describe recent advances in cancer
Published in Clinical Oncology Week, July 23rd, 2007
New investigation results, "Isolation of a novel mouse gene, mSVS-1/SUSD2, reversing tumorigenic phenotypes of cancer cells in vitro," are detailed in a study published in Cancer Science. "We report isolation of a novel tumor-reversing gene, tentatively named SVS-1, encoding a protein of 820 amino acids with localization on the plasma membrane as a type I transmembrane protein. The gene was found among those downregulated in the activated oncogene-v-K-ras-transformed NIH3T3 cells, Ki3T3, with tumorigenic phenotype," investigators in Hachioji, Japan report.
"SVS-1 protein harbors several functional domains inherent to adhesion molecules. Histochemical staining of...
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