Head and Neck Cancer
Investigators at University of Giessen, Department of Urology release new data on head and neck cancer
Published in Clinical Oncology Week, July 30th, 2007
Current study results from the report, "Analysis of PIK3CA and Akt/protein kinase B in head and neck squamous cell carcinoma," have been published. According to a study from Giessen, Germany, "PIK3CA, which encodes the catalytic subunit, p110-alpha, of phosphatidylinositol 3-kinase (PI3K), is implicated in the development and progression of numerous neoplasias including head and neck squamous cell carcinoma (HNSCC). In the present study, we investigated the occurrence of PIK3CA hot-spot mutations in exons 9 and 20, the genomic gain and amplification of PIK3CA, the expression of PIK3CA mRNA and the p110 alpha protein, as well as the expression of phosphorylated-Akt (pAkt) in 33 cases of...
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