Colon Cancer
Findings from M.G. Fakih and co-researchers advance knowledge in colon cancer
Published in Clinical Oncology Week, October 29th, 2007
According to recent research from the United States, "' Uridine diphosphate glucuronosyltransferase (UGT) IAI 7/7 polymorphism has been linked with an increased risk of irinotecan-induced severe toxicities. We evaluated UGTIAI polymorphism in patients developing grade 3/4 toxicity after initiation of irinotecan to determine the frequency of this polymorphism in this population. Twenty patients with grade 3/4 irinotecan-induced toxicity underwent UGT I A I genotyping in an exploratory study."
"The frequency of UGT I A 1 7/7 and the pattern of toxicity associated with this polymorphism were described. Forty percent of patients with grade 3/4 toxicities had a UGT I A 7/7...
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