Cancer
Sidestepping cancer's chaperone
Published in Clinical Oncology Week, October 29th, 2007
Cancerous tumors are wildly unfavorable environments. Struggling for oxygen and nutrients while being bombarded by the body's defense systems, tumor cells in fact require sophisticated adaptations to survive and grow. For decades, scientists have sought ways to circumvent these adaptations to destroy cancer. Now, researchers at the University of Massachusetts Medical School (UMMS), have defined a method to target and kill cancer's "chaperone"—a protein that promotes tumor cell stability and survival—without damaging healthy cells nearby.
In "Regulation of Tumor Cell Mitochondrial Homeostasis by an Organelle-Specific Hsp90 Chaperone Network," published in the October 19...
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