Lung Cancer

Researchers from University of Texas describe findings in lung cancer

Published in Clinical Oncology Week, November 26th, 2007

According to a study from the United States, "- Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in diverse human cancers and plays a critical role in tumor cell survival, proliferation, migration, invasion, angiogenesis, and inhibition of apoptosis. The phosphorylated active form of STAT3 (pSTAT3) mediates its effects via nuclear transcriptional activity."

"However, it was recently observed that the non-phosphorylated, cytoplasmic, inactive form of STAT3 is involved in cell motility and consequently tumor invasion. It appears that, although STAT3 is not absolutely required for tumor formation, tumors that develop in the presence of...

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Source: Clinical Oncology Week (2007-11-26)

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