Colon Cancer
Studies in the area of colon cancer reported from University of Ulm, Department of Internal Medicine I
Published in Clinical Oncology Week, March 3rd, 2008
New research, 'Focal adhesion kinase mediates defects in the force-dependent reinforcement of initial integrin-cytoskeleton linkages in metastatic colon cancer cell lines,' is the subject of a report. "Micro-environmental clues, including the biophysical interpretation of the extracellular matrix, are critical to proliferation, apoptosis and migration. Here, we show that metastatic human colon cancer cell lines display altered matrix interaction," scientists in Ulm, Germany report.
"Interaction of colon cancer cells with collagen I depends on integrins (mainly alpha(1)/beta(1)) but metastatic cells display delayed spreading and reduced extension of lamellipodia. In...
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