Cancer Vaccines
Vaccine/antibody therapy effective, milder side effects in melanoma and ovarian cancer
Published in Clinical Oncology Week, March 3rd, 2008
BOSTON--One of the shortcomings of a therapy that uses millions of identical antibodies to boost the immune system's attack on cancer cells is that many patients whose tumors recede in response to the treatment also experience serious inflammatory problems, such as severe diarrhea and rashes. In a new study, a team led by Dana-Farber Cancer Institute researchers shows that giving periodic infusions of such "monoclonal" antibodies to patients who have received a widely used cancer vaccine unleashes a strong immune response to tumors, with less-harsh side effects.
The study, to be published online by the Proceedings of the National Academy of Sciences on the week of Feb....
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