Allergies
Researchers find cause of severe allergic reaction to cancer drug
Published in Clinical Oncology Week, March 24th, 2008
Clinicians have been perplexed by the fact that some patients given the drug cetuximab—an immune-based therapy commonly used to treat persons diagnosed with head and neck cancer, or colon cancer—have a severe and rapid adverse reaction to the drug. Sometimes the reaction includes anaphylaxis, a life-threatening condition characterized by a drop in blood pressure, fainting, difficulty breathing, and wheezing. Now researchers funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have discovered that specific pre-existing antibodies cause the severe reaction to the drug. This discovery in turn has enabled them to explain the...
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