Carcinoma
Reports from University of Pittsburgh describe recent advances in carcinoma
Published in Clinical Oncology Week, March 24th, 2008
"Merkel cell carcinoma ( MCC) is a rare but aggressive human skin cancer that typically affects elderly and immunosuppressed individuals, a feature suggestive of an infectious origin. We studied MCC samples by digital transcriptome subtraction and detected a fusion transcript between a previously undescribed virus T antigen and a human receptor tyrosine phosphatase," scientists in the United States report.
"Further investigation led to identification and sequence analysis of the 5387- base- pair genome of a previously unknown polyomavirus that we call Merkel cell polyomavirus ( MCV or MCPyV). MCV sequences were detected in 8 of 10 ( 80%) MCC tumors but only 5 of 59 (...
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